Investigation of the Relationship between HIWI2 Gene and Male Idiopathic Infertility

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Salimi Sara; GHORBIAN SAEID; ALIBAKHSHI REZA

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Title

Investigation of the Relationship between HIWI2 Gene and Male Idiopathic Infertility

Author(s)

Salimi Sara | GHORBIAN SAEID | ALIBAKHSHI REZA | Issue Writer Certificate

Keywords

HIWI2 GeneQ1

Idiopathic InfertilityQ2

OligozoospermiaQ2

AzoospermiaQ1

Abstract

Background: Oligospermia and Azoospermia play important roles in male infertility. HIWI genes family plays an important role in spermatogenesis from spermatogonial through protection and formation of meiosis. The single-nucleotide change in HIWI2 Gene has been reported as a genetic factor affecting male infertility. The aim of the present study was to investigate the relationship between HIWI2 (rs508485 C>T) genetic changes and the risk of idiopathic severe oligospermia and Azoospermia in infertile men. Materials and Methods: A case-control investigation was performed on 100 blood samples of men with idiopathic Azoospermia/severe Oligozoospermia and 100 blood samples of fertile men with one chilled and without historical infertility who were referred to the infertility center of Motazedi Hospital in Kermanshah during 2015-2017. To determine HIWI2 C>T gene polymorphism frequency, we used Tetra ARMS-PCR method and data was analyzed using chi-squat test. Results: In our findings, the genotype frequencies did not show a statically significant difference in dominant (P=0. 306, OR=0. 704), recessive (P=0. 359, OR=0. 786), and codominant (P>0. 05, OR=1. 000) heredity models. The allele frequencies did not reveal a statically significant difference between the two groups (P=0. 215, OR=0. 774; CI=0. 516-1. 161). Conclusion: Our investigation did not show any evidence to the effect of HIWI2 rs508485 gene polymorphism as a risk factor for idiopathic Azoospermia/severe Oligozoospermia.

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APA: Copy

Salimi, Sara, GHORBIAN, SAEID, & ALIBAKHSHI, REZA. (2019). Investigation of the Relationship between HIWI2 Gene and Male Idiopathic Infertility. PAJOUHESH DAR PEZESHKI, 43(3 ), 164-169. SID. https://sid.ir/paper/372099/en

Vancouver: Copy

Salimi Sara, GHORBIAN SAEID, ALIBAKHSHI REZA. Investigation of the Relationship between HIWI2 Gene and Male Idiopathic Infertility. PAJOUHESH DAR PEZESHKI[Internet]. 2019;43(3 ):164-169. Available from: https://sid.ir/paper/372099/en

IEEE: Copy

Sara Salimi, SAEID GHORBIAN, and REZA ALIBAKHSHI, “Investigation of the Relationship between HIWI2 Gene and Male Idiopathic Infertility,” PAJOUHESH DAR PEZESHKI, vol. 43, no. 3 , pp. 164–169, 2019, [Online]. Available: https://sid.ir/paper/372099/en

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