The Effect of Subcutaneous Infiltration of Bupivacaine and Diluted Subcutaneous Ketamine on Post-operative Pain after Cesarean Section of General Anesthesia.

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Khoshbin Masoud; Barkhordari Sharifabad Maasoumeh; Dehghan Dehnavi Fahimeh

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2019 | Volume:41 | Issue:2 (106) Page(s): 7-15

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Title

The Effect of Subcutaneous Infiltration of Bupivacaine and Diluted Subcutaneous Ketamine on Post-operative Pain after Cesarean Section of General Anesthesia.

Author(s)

Khoshbin Masoud | Barkhordari Sharifabad Maasoumeh | Dehghan Dehnavi Fahimeh | Issue Writer Certificate

Keywords

Cesarean sectionQ3

subcutaneous bupivacaineQ1

subcutaneous ketamineQ1

analgesiaQ3

Abstract

Introduction & Objective: Proper analgesia after Cesarean section helps mothers feel more comfortable and increases the mobility and ability of the mother to better care than the newborn. The purpose of this study was to compare the effect of subcutaneous infiltration of bupivacaine and diluted subcutaneous ketamine on post-operative pain after Cesarean section of general anesthesia. Materials and methods: In this double-blind randomized clinical trial study, 60 mothers who were candidates for elective Cesarean section under general anesthesia were enrolled. 30 mothers were randomly assigned to group (A) undergoing subcutaneous injection of 4 cc bupivacaine diluted to 10 cc and 30 mothers in group (B) who underwent subcutaneous injection of 50 mg of ketamine diluted to 10 cc, was injected subcutaneously at the site of the Cesarean section at the end of the operation. The pain score of 1, 6 and 12 hours after surgery was compared in two groups by VAS. In the event of the VAS more than or equal to 5 at any time, diclofenac 100 mg suppositories was given in the absence of response, was prescribed intravenous pethidine50mg. The dose and frequency of receiving suppositories and drug dose were counted and recored in a pre-determined questionnaire. Data were analyzed by SPSS software version 20. Results: Side effects in two groups including nausea, vomit, Delusion, shiver and vertigo were not significant in the first 12 hours in both groups. The mean VAS at 1, 6 and 12 hours postoperatively was significantly lower in the ketamine group than in the bupivacaine group. Mean VAS scores of patients during the first 12 hours in the ketamin group was 1. 00± 0. 69 and in the bupivacaine group was 2. 03± 1. 18 which was significant with P-value = 0. 00. The mean duration of analgesia in the diluted ketamine group was significantly more than the diluted bupivacaine group. The mean dose of diclofenac suppository in both bupivacaine and ketamine groups was2. 83± 0. 91 and2. 20± 0. 76 respectively and p-value = 0. 005. the rete of intake of pain reliever in the ketamine recipient group was lower than the group receiving bupivacaine. Conclusion: Independent variables were similar in both groups p-value<0/05. Ketamine reduced pain at 1, 6, 12 hours after surgery. Nausea, vomit, Delusion, shiver and vertigo are similar in both groups. Subcutaneous injection of diluted ketamine is recommended in elective Cesarean section.

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APA: Copy

Khoshbin, Masoud, Barkhordari Sharifabad, Maasoumeh, & Dehghan Dehnavi, Fahimeh. (2019). The Effect of Subcutaneous Infiltration of Bupivacaine and Diluted Subcutaneous Ketamine on Post-operative Pain after Cesarean Section of General Anesthesia.. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 41(2 (106) ), 7-15. SID. https://sid.ir/paper/372110/en

Vancouver: Copy

Khoshbin Masoud, Barkhordari Sharifabad Maasoumeh, Dehghan Dehnavi Fahimeh. The Effect of Subcutaneous Infiltration of Bupivacaine and Diluted Subcutaneous Ketamine on Post-operative Pain after Cesarean Section of General Anesthesia.. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2019;41(2 (106) ):7-15. Available from: https://sid.ir/paper/372110/en

IEEE: Copy

Masoud Khoshbin, Maasoumeh Barkhordari Sharifabad, and Fahimeh Dehghan Dehnavi, “The Effect of Subcutaneous Infiltration of Bupivacaine and Diluted Subcutaneous Ketamine on Post-operative Pain after Cesarean Section of General Anesthesia.,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 41, no. 2 (106) , pp. 7–15, 2019, [Online]. Available: https://sid.ir/paper/372110/en

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