Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors in patients undergoing coronary artery bypass surgery: Clinical trial Study

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ALMASI JAVAD; AZIZBEIGI KAMAL; MOHAMMAD ZADE SALAMAT KHALED; NAGHSHTABRIZI BEHSHAD; AZARBAYJANI MOHAMMAD ALI

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:21 | Issue:4 (72) Page(s): 14-21

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Title

Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors in patients undergoing coronary artery bypass surgery: Clinical trial Study

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Keywords

Coronary artery bypass surgeryQ2

ResveratrolQ1

rehabilitation exercise trainingQ3

Interleukin-6Q1

C-reactive proteinQ1

Abstract

Background and Objective: Coronary artery disease is one of the most important health issues worldwide which antioxidants are among the agents can play important role in reducing cardiovascular diseases. The present study was done to determine the effect of Resveratrol supplementation during rehabilitation exercises training on systemic inflammation factors in patients after Coronary artery bypass surgery. Methods: This clinical trial study was done on 40 patients after Coronary artery bypass surgery in the heart rehabilitation center of Farshchian cardiovascular specialist hospital in Hamadan, Iran during 2016. Patients randomly assigned into four groups including control (Con; n=10), Resveratrol supplementation (RS; n=10), rehabilitation exercise training (RXT; n=10), and Resveratrol supplements-cardiac rehabilitation exercise training (REX; n=10). rehabilitation exercise training was done in nonconsecutive three sessions for eight weeks in the form of endurance training at 50-70% HRmax for 15-20 min, and resistance training at 20-50 one-repetition maximum (1RM). The number of repetitions was 8-15 reps, where done based on the capacity and ability of the subject, while the subjects in supplement groups consumed daily 400 mg of Resveratrol. Blood sample was done before and 48 hours after exercise training and supplementation. Concentrations of tumor necrosis factor alpha (TNFα ), Interleukin-6 (IL-6), Interleukin 1 beta (IL-1β ) and C-reactive protein (CRP) were measured in the plasma. Results: CRP, TNF-alpha and IL-1beta and IL-6 were significantly reduced in Resveratrol supplementscardiac rehabilitation exercise training group in compared to control, Resveratrol supplementation and rehabilitation exercise training groups (P˂ 0. 05). Conclusion: This study showed that combination of consuming Resveratrol with rehabilitation exercise training in reducing some inflammatory factors was evaluated selectively, more effective than rehabilitation exercise training and Resveratrol supplementation alone.

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The Simultaneous Effects of Aerobic Training and Octopamine on the Mitophagy of the Brown Adipose Tissue after the Induction of Intoxication by Deeply Heated Oil in Male Wistar Rats

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APA: Copy

ALMASI, JAVAD, AZIZBEIGI, KAMAL, MOHAMMAD ZADE SALAMAT, KHALED, NAGHSHTABRIZI, BEHSHAD, & AZARBAYJANI, MOHAMMAD ALI. (2020). Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors in patients undergoing coronary artery bypass surgery: Clinical trial Study. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 21(4 (72)), 14-21. SID. https://sid.ir/paper/372199/en

Vancouver: Copy

ALMASI JAVAD, AZIZBEIGI KAMAL, MOHAMMAD ZADE SALAMAT KHALED, NAGHSHTABRIZI BEHSHAD, AZARBAYJANI MOHAMMAD ALI. Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors in patients undergoing coronary artery bypass surgery: Clinical trial Study. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;21(4 (72)):14-21. Available from: https://sid.ir/paper/372199/en

IEEE: Copy

JAVAD ALMASI, KAMAL AZIZBEIGI, KHALED MOHAMMAD ZADE SALAMAT, BEHSHAD NAGHSHTABRIZI, and MOHAMMAD ALI AZARBAYJANI, “Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors in patients undergoing coronary artery bypass surgery: Clinical trial Study,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 4 (72), pp. 14–21, 2020, [Online]. Available: https://sid.ir/paper/372199/en

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