IMPAIRED RENAL TUBULAR FUNCTION IN PEDIATRIC PATIENTS WITH β-THALASSEMIA MAJOR

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAZAHERI MOZHGAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2009 | Volume:10 | Issue:2 (30) Page(s): 119-124

Download Full-Text

Persian Verion

View:

914

Download:

Cites:

Information Journal Paper

Title

IMPAIRED RENAL TUBULAR FUNCTION IN PEDIATRIC PATIENTS WITH β-THALASSEMIA MAJOR

Author(s)

MAZAHERI MOZHGAN | Issue Writer Certificate

Keywords

β-THALASSEMIA MAJORQ3

RENAL TUBULAR FUNCTIONQ2

NAG (N.ACETYL-β.D.GLUCOSAMINIDASE)Q2

Abstract

Introduction: b-thalassemia major due to ineffective erythrocyte life span leads to severe anemia requiring regular transfusion, which it can lead to major organs damage. Renal damage can be attributed to chronic anemia, iron over load and or defferoxamin toxicity. The object of this study was to analyze renal tubular and glomerular function in pediatric patients with beta-thalassemia major.Materials and Methods: 39 patients with b -thalassemia major whose mean ages were 11.8 yr and 22 sex and age matched healthy children as control group were studied. Blood rine samplesand uwere obtained for measuring biochemical markers. Urinary N-Acetyl- b.D.glucosaminidase (NAG) and urine NAG to creatine ratio (U Cr /NAGratio) were measured.Results: No significant differences were found between serum BUN, creatinine, and also creatinine clearance between both groups. Also there were no significant differences in urine osmolality between patients and controls. Urine NAG was significantly higher in thalassemic patients than control group (p<0.000). There was positive relation between urinary NAG and duration of illness(r=0314, p<0.01). There was no significant relationship between urinary NAG and serum ferritin. Finally, no significant difference was found in GFR of both groups.Conclusion: Our study showed RENAL TUBULAR FUNCTION is impaired in in patients with b-thalassemia major as indicated with increased urinary NAG. Further, we have found a positive relationship between urinary NAG and duration of disease. Thus, in spite of normal GFR and other biochemical marker such as BUN and creatinine, increased urinary NAG may be as an early marker of renal disease in patients with b-thalassemia major.

Cites

No record.

References

Cite

APA: Copy

MAZAHERI, MOZHGAN. (2009). IMPAIRED RENAL TUBULAR FUNCTION IN PEDIATRIC PATIENTS WITH β-THALASSEMIA MAJOR. KOOMESH, 10(2 (30)), 119-124. SID. https://sid.ir/paper/37258/en

Vancouver: Copy

MAZAHERI MOZHGAN. IMPAIRED RENAL TUBULAR FUNCTION IN PEDIATRIC PATIENTS WITH β-THALASSEMIA MAJOR. KOOMESH[Internet]. 2009;10(2 (30)):119-124. Available from: https://sid.ir/paper/37258/en

IEEE: Copy

MOZHGAN MAZAHERI, “IMPAIRED RENAL TUBULAR FUNCTION IN PEDIATRIC PATIENTS WITH β-THALASSEMIA MAJOR,” KOOMESH, vol. 10, no. 2 (30), pp. 119–124, 2009, [Online]. Available: https://sid.ir/paper/37258/en

Related Journal Papers