Antibacterial Effects of Chitosan Nanoparticles Loaded with Amoxicillin and Clavulanic acid against Methicillin Resistant Staphylococcus aureus Strains

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AKBARI N.; ASHRAFI F.; SALEHI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:27 | Issue:2 Page(s): 187-197

Download Full-Text

Persian Verion

View:

437

Download:

Cites:

Information Journal Paper

Title

Antibacterial Effects of Chitosan Nanoparticles Loaded with Amoxicillin and Clavulanic acid against Methicillin Resistant Staphylococcus aureus Strains

Author(s)

AKBARI N. | ASHRAFI F. | SALEHI M. | Issue Writer Certificate

Keywords

AmoxicillinQ1

Chitosan nanoparticlesQ1

Clavulanic acidQ1

Methicillin resistant Staphylococcus aureusQ1

Abstract

Introduction: Antibiotic-carrying nanoparticles have cytotoxic effects on drug-resistant bacteria. The aim of the present study was to evaluate the effect of Chitosan nanoparticles carrying Amoxicillin and Clavulanic acid on the viability of staphylococcus aureus strains. Materials & Methods: In this study, Chitosan nanoparticles were prepared by ionic gelation method and were loaded by Amoxicillin and Clavulanic acid leading to the production of nanoparticles with dimension less than 100 nm. To evaluate the effect of different nanoparticle concentration on the bacteria, chitosan and Amoxicillin concentrations of 0. 25-8 and 1-128 μ g/ml were prepared, respectively, using the microdilution method. Subsequently, 100 nm of different chitosan nanoparticle concentration with antibiotic was transferred to each well and 1 μ l of bacterial suspension was added to the wells. Turbidity in the wells was observed without armed eye and the light absorbance was read in the wavelength range of 630 nm by enzyme-linked immunosorbent assay. Findings: The results showed that minimum inhibitory concentrations of Chitosan nanoparticles carrying Amoxicillin and clavulanic were 0. 9 and 3. 6 μ g/ml in susceptible and resistant specimens, respectively. Moreover, their minimum destructive concentrations were obtained at 1. 8 and 7. 2 μ g/ml, respectively. Discussion & Conclusions: According to the results, the obtained combination showed more antibacterial effectiveness, compared to chitosan and Amoxicillin alone. This reveals the synergistic effect of Amoxicillin with Clavulanic acid and chitosan.

Cites

No record.

References

No record.

Cite

APA: Copy

AKBARI, N., ASHRAFI, F., & SALEHI, M.. (2019). Antibacterial Effects of Chitosan Nanoparticles Loaded with Amoxicillin and Clavulanic acid against Methicillin Resistant Staphylococcus aureus Strains. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 27(2 ), 187-197. SID. https://sid.ir/paper/372602/en

Vancouver: Copy

AKBARI N., ASHRAFI F., SALEHI M.. Antibacterial Effects of Chitosan Nanoparticles Loaded with Amoxicillin and Clavulanic acid against Methicillin Resistant Staphylococcus aureus Strains. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;27(2 ):187-197. Available from: https://sid.ir/paper/372602/en

IEEE: Copy

N. AKBARI, F. ASHRAFI, and M. SALEHI, “Antibacterial Effects of Chitosan Nanoparticles Loaded with Amoxicillin and Clavulanic acid against Methicillin Resistant Staphylococcus aureus Strains,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 2 , pp. 187–197, 2019, [Online]. Available: https://sid.ir/paper/372602/en

Related Journal Papers