Comparison of Hemodynamic and Analgesic Effects of Subcutaneous Dexmedetomidine Versus Marcaine 0. 5% on Herniorrhaphy Scheduled Patients

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Maktoobian Mehdi; Pazooki Shirin; Moudir Hesamaldin; KAMALI ALIREZA; Naeemi Amirreza

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2019 | Volume:41 | Issue:2 (106) Page(s): 46-55

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Title

Comparison of Hemodynamic and Analgesic Effects of Subcutaneous Dexmedetomidine Versus Marcaine 0. 5% on Herniorrhaphy Scheduled Patients

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Keywords

DexmedetomidineQ2

Hemodynamic changesQ2

Marcaine 0.5%Q1

Subcutaneous injectionQ1

Abstract

Introduction: The study addressed the comparative hemodynamic and analgesic effects of subcutaneous Dexmedetomidine versus marcaine 0. 5% on herniorrhaphy scheduled patients, as well as postoperative pain management. Materials and methods: This double-blind trial enrolled three groups of patients (N=120) scheduled for herniorrhaphy at Valiasr Hospital (Arak, Iran): (i) MAR-DEX group, receiving marcaine 0. 5% (5 mg) + Dexmedetomidine (1 mcg/kg), (ii) MAR group, marcaine 0. 5% (5 mg), and (iii) PBO group, placebo, subcutaneously. We measured vital signs (BP/HR/SaO2), as well as pain scores (using the visual analog scale) at recovery and certain time points (1, 2, 4, 6, 12, 24 hrs post-op), and the overall opioid administered postoperatively and side effects. This was afterward followed by an SPSS (20) analysis. Results: Lower pain was revealed in the MAR-DEX group and higher one in the PBO group (p = 0. 0001), whereas the lowest opioid use was observed in the MAR-DEX group (p = 0. 0001). Conclusion: Adding Dexmedetomidine had benefits of relieving pain and reducing opioid use without any side effects.

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APA: Copy

Maktoobian, Mehdi, Pazooki, Shirin, Moudir, Hesamaldin, KAMALI, ALIREZA, & Naeemi, Amirreza. (2019). Comparison of Hemodynamic and Analgesic Effects of Subcutaneous Dexmedetomidine Versus Marcaine 0. 5% on Herniorrhaphy Scheduled Patients. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 41(2 (106) ), 46-55. SID. https://sid.ir/paper/373688/en

Vancouver: Copy

Maktoobian Mehdi, Pazooki Shirin, Moudir Hesamaldin, KAMALI ALIREZA, Naeemi Amirreza. Comparison of Hemodynamic and Analgesic Effects of Subcutaneous Dexmedetomidine Versus Marcaine 0. 5% on Herniorrhaphy Scheduled Patients. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2019;41(2 (106) ):46-55. Available from: https://sid.ir/paper/373688/en

IEEE: Copy

Mehdi Maktoobian, Shirin Pazooki, Hesamaldin Moudir, ALIREZA KAMALI, and Amirreza Naeemi, “Comparison of Hemodynamic and Analgesic Effects of Subcutaneous Dexmedetomidine Versus Marcaine 0. 5% on Herniorrhaphy Scheduled Patients,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 41, no. 2 (106) , pp. 46–55, 2019, [Online]. Available: https://sid.ir/paper/373688/en

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