Elevated Serum Levels of IL-6 and TNF-a in Patients with Irritable Bowel Syndrome

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AZIZIAN M.; TURKI H.; MIRZAEI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Ilam University of Medical Sciences Year:2019 | Volume:27 | Issue:2 Page(s): 21-29

Download Full-Text

Persian Verion

View:

519

Download:

Cites:

Information Journal Paper

Title

Elevated Serum Levels of IL-6 and TNF-a in Patients with Irritable Bowel Syndrome

Author(s)

AZIZIAN M. | TURKI H. | MIRZAEI A. | Issue Writer Certificate

Keywords

Enzyme-linked immunosorbent assayQ1

Interleukin-6Q1

Irritable bowel syndromeQ1

Tumor necrosis factor-aQ2

Abstract

Introduction: Irritable bowel syndrome (IBS) is accompanied by abdominal pain and intestinal discomforts. A line of evidence shows that the immune system plays important roles in the pathogenesis of the disease. Two main cytokines directing the immune system are IL-6 and TNF-α which may play a role in the immunopathogenesis of this disease. The present study aimed at investigating the serum levels of these cytokines in patients suffering from IBS. Materials & Methods: This comparative case-control study was conducted on 40 patients suffering from IBS (case group) and 40 people who were affected by the symptoms of gastrointestinal disorders but not suffering from IBS (control group). The serum levels of TNF-α and IL-6 cytokines were measured using enzymelinked immunosorbent assay. The amount of the above-mentioned cytokines was compared using independent-t-test in both groups. Ethics code: EC/92/H/132 Findings: The results showed significantly higher levels of IL-6 and TNF-α in IBS patients, compared to those in the control group (P=0. 0001). According to the results obtained from the Spearman rank correlation coefficient, there was a strong correlation between the serum levels of IL-6 (Ρ =0. 799, P=0. 000) and TNF-α (Ρ =0. 788, P=0. 000) cytokines with IBS development. Discussion & Conclusions: This study shows that serum levels of TNF-α and IL-6 cytokines are significantly higher in the case group with IBS. Moreover, there is an association between serum levels of IL-6 and TNF-α with the pathogenesis of IBS.

Cites

No record.

References

No record.

Cite

APA: Copy

AZIZIAN, M., TURKI, H., & MIRZAEI, A.. (2019). Elevated Serum Levels of IL-6 and TNF-a in Patients with Irritable Bowel Syndrome. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 27(2 ), 21-29. SID. https://sid.ir/paper/374143/en

Vancouver: Copy

AZIZIAN M., TURKI H., MIRZAEI A.. Elevated Serum Levels of IL-6 and TNF-a in Patients with Irritable Bowel Syndrome. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;27(2 ):21-29. Available from: https://sid.ir/paper/374143/en

IEEE: Copy

M. AZIZIAN, H. TURKI, and A. MIRZAEI, “Elevated Serum Levels of IL-6 and TNF-a in Patients with Irritable Bowel Syndrome,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 2 , pp. 21–29, 2019, [Online]. Available: https://sid.ir/paper/374143/en

Related Journal Papers