EFFECTS OF VALERIANE OFFICINALIS, SATUREJA HORTENSIS, AND MENTHA PIPERITA EXTRACTS ON THE WITHDRAWAL SYNDROME SIGNS IN MICE

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VAFAEI ABAS ALI; MILADI GORJI H.; TAHERIAN ABAS ALI; BAGERIAN M.

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Journal: Koomesh Year:2011 | Volume:12 | Issue:3 (39) Page(s): 342-347

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Title

EFFECTS OF VALERIANE OFFICINALIS, SATUREJA HORTENSIS, AND MENTHA PIPERITA EXTRACTS ON THE WITHDRAWAL SYNDROME SIGNS IN MICE

Author(s)

VAFAEI ABAS ALI | MILADI GORJI H. | TAHERIAN ABAS ALI | BAGERIAN M. | Issue Writer Certificate

Keywords

VALERIANE OFFICINALISQ3

SATUREJA HORTENSISQ2

MENTHA PIPERITAQ3

MORPHINE WITHDRAWAL SYNDROMEQ3

NALOXONEQ2

MICEQ2

Abstract

Introduction: Several studies have demonstrated the antinociceptive, anti-inflammatory, sedative and smooth muscle relaxant activities of the VALERIANE OFFICINALIS (VO), SATUREJA HORTENSIS (SH), and MENTHA PIPERITA (MP). The aim of this study was to determine the effects of the aqueous or hydroalcoholic extracts from these plants on MORPHINE WITHDRAWAL SYNDROME signs in MICE.Materials and Methods: 112 male albino MICE (25-30 g) were used. Morphine was used to produce drug dependency by Marshall method. Different doses of the aqueous extracts of VO (25, 50, 100 mg/kg) and SH (25, 50, 100, 200 mg/kg IP) and the hydroalcoholic extract of MP (50, 100, 200, 500 mg/kg IP) were injected to morphine-dependent MICE 30 min before the NALOXONE injection (2mg/kg). Control MICE received saline. The severity of the morphine withdrawal responses was estimated by recordeing the number of jumping and the amount of weight feces during 3o min after NALOXONE injection.Results: The results showed that the extracts of VO (25 mg/kg), SH (200 mg/kg), and MP (all doses) significantly (P<0.05) decreased the number of jumping. Also, the VO (50 and 100 mg/kg), SH and MP (all tested doses) significantly decreased the weight of stool.Conclusion: Our findings indicate that the extracts of VO, SH, and MP may diminish the MORPHINE WITHDRAWAL SYNDROME signs.

Cites

EFFECT OF AQUEOUS EXTRACT OF SATUREJA HORTENSIS ON GASTRIC ULCER INDUCED BY ACETIC ACID IN RATS

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APA: Copy

VAFAEI, ABAS ALI, MILADI GORJI, H., TAHERIAN, ABAS ALI, & BAGERIAN, M.. (2011). EFFECTS OF VALERIANE OFFICINALIS, SATUREJA HORTENSIS, AND MENTHA PIPERITA EXTRACTS ON THE WITHDRAWAL SYNDROME SIGNS IN MICE. KOOMESH, 12(3 (39)), 342-347. SID. https://sid.ir/paper/37435/en

Vancouver: Copy

VAFAEI ABAS ALI, MILADI GORJI H., TAHERIAN ABAS ALI, BAGERIAN M.. EFFECTS OF VALERIANE OFFICINALIS, SATUREJA HORTENSIS, AND MENTHA PIPERITA EXTRACTS ON THE WITHDRAWAL SYNDROME SIGNS IN MICE. KOOMESH[Internet]. 2011;12(3 (39)):342-347. Available from: https://sid.ir/paper/37435/en

IEEE: Copy

ABAS ALI VAFAEI, H. MILADI GORJI, ABAS ALI TAHERIAN, and M. BAGERIAN, “EFFECTS OF VALERIANE OFFICINALIS, SATUREJA HORTENSIS, AND MENTHA PIPERITA EXTRACTS ON THE WITHDRAWAL SYNDROME SIGNS IN MICE,” KOOMESH, vol. 12, no. 3 (39), pp. 342–347, 2011, [Online]. Available: https://sid.ir/paper/37435/en

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