ANTI-HYPERALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ACHILLEA SANTOLINA AND STACHYS ATHORECALYX EXTRACTS ON COMPLETE FREUND'S ADJUVANT–INDUCED SHORT-TERM INFLAMMATION IN MALE WISTAR RATS

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TEKIEH E.; AKBARI AKHTAR; MANAHEJI H.; REZAZADEH SH.A.; ZARINGHALAM J.

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Journal: Koomesh Year:2011 | Volume:12 | Issue:3 (39) Page(s): 305-313

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Title

ANTI-HYPERALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ACHILLEA SANTOLINA AND STACHYS ATHORECALYX EXTRACTS ON COMPLETE FREUND'S ADJUVANT–INDUCED SHORT-TERM INFLAMMATION IN MALE WISTAR RATS

Author(s)

Keywords

HYPERALGESIAQ2

INFLAMMATIONQ2

STACHYS ATHORECALYXQ2

ACHILLEA SANTOLINAQ2

RATQ2

Abstract

Introduction: Immune system is involved in the etiology and path physiologic mechanisms of INFLAMMATION. Medicinal plants are an important source of substances which are claimed to induce nonspecific immune modulator effects. Given the above information and the role of IL-6 in INFLAMMATION and pain induction, this study investigated the effects of ACHILLEA SANTOLINA and STACHYS ATHORECALYX methanolic and defatted extracts on cmplete Freund's adjuvant (CFA) -induced short term INFLAMMATION in male Wistar RATs Materials and Methods: INFLAMMATION was induced on day zero by CFA injection in hind paw of RATs.Methanolic and defatted extractions were prepared form aerial parts of both plants. 50, 100 and 200 mg/kg doses of extracts were selected for IP treatment during 6 days after CFA injection.Results: Results indicated dose related effects of A. santolina and S. athorecalyx extracts on edema, HYPERALGESIA and serum IL-6 level during INFLAMMATION. Although, both methanolic and defatted extracts of S. athorecalyx showed a significant reduction in the inflammatory symptoms, no significant differences was observed between these two kinds of extracts of S.athorecalyx with respect to their anti inflammatory effects. Only methanolic extract of A. santolina was effective during CFA-induced INFLAMMATION. Conclusion: These results could suggest that short-term administration of A. santolina and S. athorecalyx extracts possess potent anti-inflammatory effects and modulate paw edema, HYPERALGESIA and serum IL-6 level during CFA–induced INFLAMMATION. In addition, these dose-dependent effects may mediate via different extract supplements which need more investigations.

Cites

INVESTIGATING THE NEUROPROTECTIVE EFFECT OF ALCHOLIC EXTRACTS OF ACHILLEA BIEBERSTEINII LEAVE ON Α MOTONEURONS AFTER SCIATIC NERVE COMPRESSION IN RATS

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APA: Copy

TEKIEH, E., AKBARI, AKHTAR, MANAHEJI, H., REZAZADEH, SH.A., & ZARINGHALAM, J.. (2011). ANTI-HYPERALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ACHILLEA SANTOLINA AND STACHYS ATHORECALYX EXTRACTS ON COMPLETE FREUND'S ADJUVANT–INDUCED SHORT-TERM INFLAMMATION IN MALE WISTAR RATS. KOOMESH, 12(3 (39)), 305-313. SID. https://sid.ir/paper/37440/en

Vancouver: Copy

TEKIEH E., AKBARI AKHTAR, MANAHEJI H., REZAZADEH SH.A., ZARINGHALAM J.. ANTI-HYPERALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ACHILLEA SANTOLINA AND STACHYS ATHORECALYX EXTRACTS ON COMPLETE FREUND'S ADJUVANT–INDUCED SHORT-TERM INFLAMMATION IN MALE WISTAR RATS. KOOMESH[Internet]. 2011;12(3 (39)):305-313. Available from: https://sid.ir/paper/37440/en

IEEE: Copy

E. TEKIEH, AKHTAR AKBARI, H. MANAHEJI, SH.A. REZAZADEH, and J. ZARINGHALAM, “ANTI-HYPERALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ACHILLEA SANTOLINA AND STACHYS ATHORECALYX EXTRACTS ON COMPLETE FREUND'S ADJUVANT–INDUCED SHORT-TERM INFLAMMATION IN MALE WISTAR RATS,” KOOMESH, vol. 12, no. 3 (39), pp. 305–313, 2011, [Online]. Available: https://sid.ir/paper/37440/en

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