ABORTIVE EFFECT OF BOSWELLIA HYDROALCOHOLIC EXTRACT IN MICE

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EMAMI ASRIN; KHAZAEI MOHAMMAD RASOOL; KHAZAEI MOZAFAR

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Journal: Koomesh Year:2016 | Volume:17 | Issue:2 (58) Page(s): 329-335

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Information Journal Paper

Title

ABORTIVE EFFECT OF BOSWELLIA HYDROALCOHOLIC EXTRACT IN MICE

Author(s)

EMAMI ASRIN | KHAZAEI MOHAMMAD RASOOL | KHAZAEI MOZAFAR | Issue Writer Certificate

Keywords

BOSWELLIAQ2

ABORTIONQ3

MICEQ2

Abstract

Introduction: In traditional medicine, BOSWELLIA serrata (Burseraceae family) has been used for its various effects such as enhancing learning and memory. However, some side effects have been mentioned with emphasizing on a probability for ABORTION. Therefore, the aim of this study was to evaluate BOSWELLIA serrata abortive effect in MICE.Materials and Methods: In this experimental study, virgin young female MICE (balb/c) with a 25-30 gr weight were used in three different time periods: before fertilization, pre-implantation period (days 1-5 of gestation) and during implantation (days 5-7 of gestation). In each study four groups (n=8) were used including experimental groups who received 50, 100 and 200 mg/kg of BOSWELLIA extract (IP), respectively and a control group (received 0.3 ml distilled water (IP). Animals were sacrificed on days 11-13 of pregnancy and the number of implantation sites were counted.Results: The average number of implantation sites in control and 50, 100 and 200mg/kg concentrations of extract in the pre-fertilization period were 9.83±1.17, 6.5±1.76 , 6.5±1.22 and 6.67±2.07, respectively (P=0.003). In the pre-implantation period they were 8.5±0.91 6±1.31, 5±1.16 and 3.29±1.27, respectively (P=0.032), and during implantation were 9.38±2.77, 6.38±3.1, 5.25±2.25 and 3.57±2.17, respectively (P=0.035). Reductions in the number of implantation sites were found to be dose-dependent in preimplantation and implantation periods.Conclusion: Our findings showed that BOSWELLIA exert has abortive effects in MICE and the stronger effect was observed with higher doses during preimplantation and implantation periods.

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APA: Copy

EMAMI, ASRIN, KHAZAEI, MOHAMMAD RASOOL, & KHAZAEI, MOZAFAR. (2016). ABORTIVE EFFECT OF BOSWELLIA HYDROALCOHOLIC EXTRACT IN MICE. KOOMESH, 17(2 (58)), 329-335. SID. https://sid.ir/paper/37514/en

Vancouver: Copy

EMAMI ASRIN, KHAZAEI MOHAMMAD RASOOL, KHAZAEI MOZAFAR. ABORTIVE EFFECT OF BOSWELLIA HYDROALCOHOLIC EXTRACT IN MICE. KOOMESH[Internet]. 2016;17(2 (58)):329-335. Available from: https://sid.ir/paper/37514/en

IEEE: Copy

ASRIN EMAMI, MOHAMMAD RASOOL KHAZAEI, and MOZAFAR KHAZAEI, “ABORTIVE EFFECT OF BOSWELLIA HYDROALCOHOLIC EXTRACT IN MICE,” KOOMESH, vol. 17, no. 2 (58), pp. 329–335, 2016, [Online]. Available: https://sid.ir/paper/37514/en

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