Comparative Evaluation of the Efficacy of Milk and Milk Containing Nano-Curcumin on Lead Toxicity in Huh7-1x-ARE-luc cell-line

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Seyed Ahmadian S.M.; JALILI SH.; SHIRZAD H.; SADEGHIZADEH M.

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Journal: Pathobiology Research Year:2019 | Volume:22 | Issue:4 Page(s): 181-187

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Title

Comparative Evaluation of the Efficacy of Milk and Milk Containing Nano-Curcumin on Lead Toxicity in Huh7-1x-ARE-luc cell-line

Author(s)

Seyed Ahmadian S.M. | JALILI SH. | SHIRZAD H. | SADEGHIZADEH M. | Issue Writer Certificate

Keywords

Huh7Q1

1xQ2

AREQ2

luc Biosensor;Lead;NanoQ2

Curcumin;Milk;Luciferase AssayQ1

Abstract

Aims Oxidative substances ARE chemically reactive molecules and a byproduct of oxidative metabolism. Oxidative stress is one of the most lethal mechanisms in the toxicity of heavy metals such as lead. Since curcumin is an active ingredient in turmeric and has many properties, including antioxidant properties, the present study was conducted to evaluate the effect of milk and milk containing nano-curcumin on lead toxicity and to determine the effective concentration of nano-curcumin in controlling lead toxicity. Materials & Methods In the present study, the Huh7-1x-ARE-luc cell line, a biosensor of oxidative stress, was treated with 30μ M of lead as a strong oxidant. Then the antioxidant effect of low-fat and high-fat milk (20, 40, and 80μ L), nano-curcumin in antioxidant concentrations (4 and 8μ M) and simultaneous treatment with the combination of these two antioxidants was tested using Luciferase assay. Results Based on statistical analyses, the combination of milk and nano-curcumin (combination of 30μ M lead, 20μ L milk and 4μ M nano-curcumin) was able to significantly reduce lead toxicity at low concentrations of milk compAREd to the milk without nano-curcumin (combination of 30μ M lead and 80μ L milk), with RLU of 1266 and 34000, respectively. Discussion & Conclusion Nano-curcumin reveals a stronger antioxidant effect compAREd to milk, and ultimately, the combination of nano-curcumin and milk greatly neutralizes lead toxicity.

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ارزیابی پارامترهای استرس اکسیداتیو در سرم خون رانندگان درون شهری در مقایسه با رانندگان برون شهری با نگاه تاثیر آلاینده های ترافیکی: مطالعه همگروهی آینده نگر

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APA: Copy

Seyed Ahmadian, S.M., JALILI, SH., SHIRZAD, H., & SADEGHIZADEH, M.. (2019). Comparative Evaluation of the Efficacy of Milk and Milk Containing Nano-Curcumin on Lead Toxicity in Huh7-1x-ARE-luc cell-line. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 22(4 ), 181-187. SID. https://sid.ir/paper/376537/en

Vancouver: Copy

Seyed Ahmadian S.M., JALILI SH., SHIRZAD H., SADEGHIZADEH M.. Comparative Evaluation of the Efficacy of Milk and Milk Containing Nano-Curcumin on Lead Toxicity in Huh7-1x-ARE-luc cell-line. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2019;22(4 ):181-187. Available from: https://sid.ir/paper/376537/en

IEEE: Copy

S.M. Seyed Ahmadian, SH. JALILI, H. SHIRZAD, and M. SADEGHIZADEH, “Comparative Evaluation of the Efficacy of Milk and Milk Containing Nano-Curcumin on Lead Toxicity in Huh7-1x-ARE-luc cell-line,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 22, no. 4 , pp. 181–187, 2019, [Online]. Available: https://sid.ir/paper/376537/en

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