Evaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection

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TAVANAEE SANI ASHRAF; JARAHI LIDA; Saberi Marzieh

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2019 | Volume:76 | Issue:12 Page(s): 792-798

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Title

Evaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection

Author(s)

TAVANAEE SANI ASHRAF | JARAHI LIDA | Saberi Marzieh | Issue Writer Certificate

Keywords

co-infectionQ1

HIVQ2

human T-lymphotropic virus 1Q1

opportunistic infectionsQ2

Abstract

Background: In the last 10 years, co-infection of human immunodeficiency virus/human T-cell leukemia virus-1 (HIV/HTLV-1) has emerged as a worldwide health problem. These viruses has the same route to infect human but different effects on CD4 positive T-cells. There was controversial results about the influence of coinfection HIV/HTLV-1 pathogenesis. This study compared clinical course and laboratory findings in HIV/HTLV-1 co-infection with HIV mono infection. Methods: This historical cohort study carried in Mashhad Consultation Center of Infective and Behavior Diseases, Mashhad, Iran, from April 2013 to March 2017. Persons who referred evaluated by the enzyme-linked immunosorbent assay (ELISA), then patients with positive ELISA test rechecked by ELISA and Western blot. Platelet count, WBC count, neutrophils count, positive CD4 T-cells, staging and disease severity evaluated at diagnosis, in starting and after of antiretroviral therapy in mono and co-infected patients. Demographic characteristics, including age, educational level, occupational state, marriage situation, past medical history and high-risk behaviors were extracted from the files. Results: Of 64 patients enrolled in this study, 61 persons were male. Of 64 participants patients, 42 persons were infected with HIV (35 persons of them were positive for hepatitis C virus), other 22 positive HIV cases, were co infected by HTLV-1 too (18 persons were positive for hepatitis C virus (HCV). Co infected patients had more history of high-risk situations specially intravenous drug abuse. The most common opportunistic infections was cryptogenic tuberculosis (TB), candidiasis and military TB. opportunistic infections and lab findings (except for CD4 positive T-cell) were the same in both group. Clinical severity and disease staging did not differ significantly between two groups. Death was more common in co-infected group. Conclusion: Clinical course in human T-cell leukemia virus-1 (HTLV-1) co-infection has not obvious differences with previously HIV patients compare with only HIV infected patients. In co-infection with the onset of treatment the increase in the level of CD4 positive cells was higher than that HIV infection.

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APA: Copy

TAVANAEE SANI, ASHRAF, JARAHI, LIDA, & Saberi, Marzieh. (2019). Evaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 76(12 ), 792-798. SID. https://sid.ir/paper/376669/en

Vancouver: Copy

TAVANAEE SANI ASHRAF, JARAHI LIDA, Saberi Marzieh. Evaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2019;76(12 ):792-798. Available from: https://sid.ir/paper/376669/en

IEEE: Copy

ASHRAF TAVANAEE SANI, LIDA JARAHI, and Marzieh Saberi, “Evaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 76, no. 12 , pp. 792–798, 2019, [Online]. Available: https://sid.ir/paper/376669/en

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