Anatical Review: Inhibiting the Degeneration of Injured Cartilage Matrix by Using the RNA Interference Technology: New Horizons in Osteoarthritis Treatment

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Akbari Moghadam N.; BAGHERI F.; BAGHABAN ESLAMINEJAD M.R.

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Journal: Pathobiology Research Year:2020 | Volume:23 | Issue:3 Page(s): 165-176

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Title

Anatical Review: Inhibiting the Degeneration of Injured Cartilage Matrix by Using the RNA Interference Technology: New Horizons in Osteoarthritis Treatment

Author(s)

Akbari Moghadam N. | BAGHERI F. | BAGHABAN ESLAMINEJAD M.R. | Issue Writer Certificate

Keywords

Articular CartilageQ2

OsteoarthritisQ1

Cartilage DegenerationQ1

RNA InterferenceQ1

Abstract

Osteoarthritis is the most common articular disease that has significantly affected the patients’ quality of life. As cartilage doesn’ t have any blood vessels and neurons, its treatment is a difficult task to do. Traditional therapeutic approaches, including the use of non-steroidal antiinflammatory drugs (NSAIDs) and surgical interventions, can only control the disease, and the joint will lose its functionality after a short period. Consequently, modern methods such as cell therapy and tissue engineering along with using various biomaterials are being attempted to repair degenerated cartilage tissue. Using interfering RNAs is another approach that targets specific destructive or malfunctioned RNA sequences and suppresses the responsible factors for cartilage tissue destruction. Hence, the degenerated tissue can gradually retain the balance between anabolic and catabolic activities. Identification of the affecting genes in degeneration or malfunctioning and their suppression has provided promising results for the treatment of diseases. In the current study, after introducing the tissue, the process of Cartilage Degeneration and Osteoarthritis development, the researches that have investigated the effect of interfering RNAs on rehabilitating cartilage tissue via inhibition of cartilage matrix destruction are reviewed.

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APA: Copy

Akbari Moghadam, N., BAGHERI, F., & BAGHABAN ESLAMINEJAD, M.R.. (2020). Anatical Review: Inhibiting the Degeneration of Injured Cartilage Matrix by Using the RNA Interference Technology: New Horizons in Osteoarthritis Treatment. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 23(3 ), 165-176. SID. https://sid.ir/paper/376674/en

Vancouver: Copy

Akbari Moghadam N., BAGHERI F., BAGHABAN ESLAMINEJAD M.R.. Anatical Review: Inhibiting the Degeneration of Injured Cartilage Matrix by Using the RNA Interference Technology: New Horizons in Osteoarthritis Treatment. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2020;23(3 ):165-176. Available from: https://sid.ir/paper/376674/en

IEEE: Copy

N. Akbari Moghadam, F. BAGHERI, and M.R. BAGHABAN ESLAMINEJAD, “Anatical Review: Inhibiting the Degeneration of Injured Cartilage Matrix by Using the RNA Interference Technology: New Horizons in Osteoarthritis Treatment,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 23, no. 3 , pp. 165–176, 2020, [Online]. Available: https://sid.ir/paper/376674/en

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