Associations of common polymorphisms in GCKR with metabolic syndrome

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Zahedi Asiyeh Sadat; SEDAGHATI KHAYAT BAHAREH; Behnami Sara; AZIZI FEREIDOUN; DANESHPOUR MARYAM SADAT

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2018 | Volume:76 | Issue:7 Page(s): 459-468

Download Full-Text

Persian Verion

View:

310

Download:

Cites:

Information Journal Paper

Title

Associations of common polymorphisms in GCKR with metabolic syndrome

Author(s)

Keywords

associationQ1

GCKRQ1

genome-wide association studyQ2

glucokinaseQ3

metabolic syndromeQ3

Tehran lipid and glucose studyQ2

Abstract

Background: metabolic syndrome (MetS) is characterized by a combination of cardiometabolic risk factors. Given that genetic factors have been shown to contribute to individual susceptibility to MetS, the identification of genetic markers for disease risk is essential. Recent studies revealed that rs780094 and rs1260326 of glucokinase regulatory gene (GCKR) are associated with serum triglycerides, plasma glucose levels and metabolic syndrome. The aim of this study was to investigate associations of GCKR gene variants with metabolic syndrome and its components. Methods: This case-control study was conducted from April to August 2017. In this study, 8710 adults (3522 males and 5188 females), over 19 years, were randomly selected from the Tehran lipid and glucose study (TLGS) population. Based on joint interim statement (JIS) criteria, the subjects were divided into two groups: case and control. Genotyping was performed by HumanOmniExpress-24 v1. 0 BeadChips (Illumina, San Diego, CA, USA). Results: Allele frequencies were in conformity with Hardy-Weinberg equilibrium. Comparisons of allele frequencies by the Chi-square test revealed that frequencies of TT genotype of both polymorphisms were significantly higher among patient group than healthy group. Logistic regression analysis with adjustment for age, gender and CRP revealed that the GCKR polymorphisms (rs1260326: odds ratio 2. 7, 95% CI 1. 6-4. 6, rs780094: odds ratio 2. 5, 95% CI 1. 5-4. 2) were significantly associated with MetS. Frequency of TT genotype was more in persons who had C-reactive protein (CRP) levels above 3 mg/l. The minor T allele of both polymorphisms was significantly associated with increases in the blood serum concentration triglyceride and to a decrease in fasting plasma glucose levels. Conclusion: The results of our study indicated that, rs780094 and rs1260326 common polymorphisms of the GCKR gene were associated with serum triglycerides levels, fasting plasma glucose levels, and metabolic syndrome in a sample of the Tehranian population (TLGS), as it was already confirmed the inverse effect of this polymorphisms on triglycerides and glucose levels in previous studies.

Cites

No record.

References

No record.

Cite

APA: Copy

Zahedi, Asiyeh Sadat, SEDAGHATI KHAYAT, BAHAREH, Behnami, Sara, AZIZI, FEREIDOUN, & DANESHPOUR, MARYAM SADAT. (2018). Associations of common polymorphisms in GCKR with metabolic syndrome. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 76(7 ), 459-468. SID. https://sid.ir/paper/376860/en

Vancouver: Copy

Zahedi Asiyeh Sadat, SEDAGHATI KHAYAT BAHAREH, Behnami Sara, AZIZI FEREIDOUN, DANESHPOUR MARYAM SADAT. Associations of common polymorphisms in GCKR with metabolic syndrome. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2018;76(7 ):459-468. Available from: https://sid.ir/paper/376860/en

IEEE: Copy

Asiyeh Sadat Zahedi, BAHAREH SEDAGHATI KHAYAT, Sara Behnami, FEREIDOUN AZIZI, and MARYAM SADAT DANESHPOUR, “Associations of common polymorphisms in GCKR with metabolic syndrome,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 76, no. 7 , pp. 459–468, 2018, [Online]. Available: https://sid.ir/paper/376860/en

Related Journal Papers