The effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats

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ASKARI BABISAN; BIJEH NAHID; RASHID LAMIR AMIR

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Journal: Journal of Sport and Exercise Physiology Year:2019 | Volume:12 | Issue:1 Page(s): 115-127

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Title

The effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats

Author(s)

ASKARI BABISAN | BIJEH NAHID | RASHID LAMIR AMIR | Issue Writer Certificate

Keywords

Exercise trainingQ1

Colorectal cancerQ1

Insulin-like growth factor-1Q1

ApoptosisQ1

Abstract

Purpose: The aim of this study was to determine the effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats Methods: A total of 28 male Wistar rats were randomly divided into 4 groups; saline injected control (Control), resistance training+saline injected (Training), resistance training+IGF-1 injected (Combined) and IGF-1 injected (Injection). Resistance training protocol consisted of climbing (three days/week, 5 reps/3 sets) a ladder carrying a load suspended from the tail for 8 weeks. IGF-1 and Three days after the last. saline (1. 5 μ g /kg/day) were injected before and after exercise sessions bout of exercise, colorectal tissues were collected and gene expression levels were analyzed using Quantitative real-time PCR. Results: In Training (p=0. 001), Combined (p=0. 001) and Injection (p=0. 002) groups, p53 expression in the colorectal significantly decreased compared with Control (p<0. 05). However, there was no significant difference between training, combined and injection groups (p>0. 05). A significant decrease of Cox-2 protein levels was observed in the Training group from the Control (p=0. 002). Cox-2 levels were significantly higher in Injection group compared to Control group (p=0. 002). In the Combined group, Cox-2 levels were significantly higher compared to Training group (p=0. 018) Conclusion: According to the results of the study, IGF-1 injection may increase the risk of Colorectal cancer and will endanger the survival of healthy cells in this tissue. our recommendation is that the use of peptides and growth factors such as IGF1 may not be useful for increasing muscle function, size and muscle strength.

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APA: Copy

ASKARI, BABISAN, BIJEH, NAHID, & RASHID LAMIR, AMIR. (2019). The effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats. PHYSIOLOGY OF SPORT AND PHYSICAL ACTIVITY, 12(1 ), 115-127. SID. https://sid.ir/paper/377121/en

Vancouver: Copy

ASKARI BABISAN, BIJEH NAHID, RASHID LAMIR AMIR. The effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats. PHYSIOLOGY OF SPORT AND PHYSICAL ACTIVITY[Internet]. 2019;12(1 ):115-127. Available from: https://sid.ir/paper/377121/en

IEEE: Copy

BABISAN ASKARI, NAHID BIJEH, and AMIR RASHID LAMIR, “The effect of 8 weeks IGF-1 injection and resistance training on Cox-2 and p53 expression in colorectal of male Wistar rats,” PHYSIOLOGY OF SPORT AND PHYSICAL ACTIVITY, vol. 12, no. 1 , pp. 115–127, 2019, [Online]. Available: https://sid.ir/paper/377121/en

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