Clinical effectiveness of Glucosamine compared to Chondroitin sulfate, hyaluronic acid on relieving pain in people with osteoarthritis: a network metaanalysis

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salehi sahlabadi Ammar; khani vahid; Kord Varkaneh Hamed; Rahmani Jamal; Zarezadeh Meysam; khorshidi Masoud; MOUSAVI SEYED MOHAMMAD; FATAHI SOMAYE

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Journal: Journal of Sabzevar University of Medical Sciences Year:2020 | Volume:27 | Issue:2 Page(s): 245-255

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Title

Clinical effectiveness of Glucosamine compared to Chondroitin sulfate, hyaluronic acid on relieving pain in people with osteoarthritis: a network metaanalysis

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Abstract

Introduction: So far, no study has ever surveyed the effectiveness of injectable and oral forms of the Glucosamine compared with chondroitin sulfate and hyaluronic acid on physical function and pain in osteoarthritic patients. The aim of this study is to evaluate the clinical efficacy of glucosamine compared with chondroitin sulfate and hyaluronic acid in relieving pain and function of people with osteoarthritis. Materials and Methods: The databases of PubMed, Scopus, Google Scholar and Cochran were searched up to November 2018. The pairwise method was used to compare the difference between the mean score of the evaluation forms before and after the intervention in two methods including direct (comparison of drugs with the control group) and nondirect (comparison of drugs with each other). Results: The present study showed that improvement in the performance of patients with osteoarthritis according to the WOMAC score, was the highest with oral form of chondroitin sulfate and then the injectable form of chondroitin sulfate and injectable form of glucosamine. Pain evaluation of patients showed the most pain reduction in the injectable form of hyaluronic acid and then the oral form of chondroitin sulfate. Pain assessment via the VAS form, showed that oral form of glucosamine alleviated the pain. Conclusion: This study demonstrated that, intake of oral form of chondroitin sulfate had the most effect on improving the physical function. Also, in the assessment of pain using WOMAC and VAS forms, the injectable form of hyaluronic acid and oral form glucosamine showed the highest improvement compared to other drugs.

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APA: Copy

salehi sahlabadi, Ammar, khani, vahid, Kord Varkaneh, Hamed, Rahmani, Jamal, Zarezadeh, Meysam, khorshidi, Masoud, MOUSAVI, SEYED MOHAMMAD, & FATAHI, SOMAYE. (2020). Clinical effectiveness of Glucosamine compared to Chondroitin sulfate, hyaluronic acid on relieving pain in people with osteoarthritis: a network metaanalysis. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 27(2 ), 245-255. SID. https://sid.ir/paper/377159/en

Vancouver: Copy

salehi sahlabadi Ammar, khani vahid, Kord Varkaneh Hamed, Rahmani Jamal, Zarezadeh Meysam, khorshidi Masoud, MOUSAVI SEYED MOHAMMAD, FATAHI SOMAYE. Clinical effectiveness of Glucosamine compared to Chondroitin sulfate, hyaluronic acid on relieving pain in people with osteoarthritis: a network metaanalysis. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;27(2 ):245-255. Available from: https://sid.ir/paper/377159/en

IEEE: Copy

Ammar salehi sahlabadi, vahid khani, Hamed Kord Varkaneh, Jamal Rahmani, Meysam Zarezadeh, Masoud khorshidi, SEYED MOHAMMAD MOUSAVI, and SOMAYE FATAHI, “Clinical effectiveness of Glucosamine compared to Chondroitin sulfate, hyaluronic acid on relieving pain in people with osteoarthritis: a network metaanalysis,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 2 , pp. 245–255, 2020, [Online]. Available: https://sid.ir/paper/377159/en

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