Measurement of pyruvate dehydrogenase enzyme in patients with diffuse large B-cell lymphoma relapse

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HADI ALI; MEHRZAD VALIOLLAH; Vaziri Nazanin; Shariati Lalaeh; VASEGHI GOLNAZ

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2020 | Volume:78 | Issue:2 Page(s): 88-92

Download Full-Text

Persian Verion

View:

472

Download:

Cites:

Information Journal Paper

Title

Measurement of pyruvate dehydrogenase enzyme in patients with diffuse large B-cell lymphoma relapse

Author(s)

Keywords

B-cell lymphomaQ1

double-blind methodQ1

pyruvate dehydrogenase enzymeQ1

recurrenceQ2

Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma (NHL), which is the most common type of lymphoma. NHL comprises a group of clinically and biologically diverse diseases, which range from indolent to aggressive clinical courses. Despite treatment advances in the last three decades with the use of combination immunotherapy, a significant fraction of patients relapses or are refractory to these treatments. Actually, there is no standard method for detection of recurrence. The purpose of this study was to evaluate the level of this enzyme in the patients with recurrent DLBCL compared to healthy controls. Methods: In this randomized double-blind, placebo-controlled trial, the serum level of pyruvate dehydrogenase (PDH) enzyme in total of 26 patients with DLBCL recurrence in compare with 26 healthy individuals in the Sayed Al-Shohada Hospital, Isfahan University of Medical Sciences in Iran from September 2016 to September 2018, were assessed. The clinical data including age criteria, the Eastern Cooperative Oncology Group (ECOG) score rating, total bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), prothrombin time and international normalized ratio (PT/INR), CT-scan, serum creatinine, platelet count, the absolute number of neutrophils, and the interval until the last treatment were gathered. After obtaining informed consent, blood samples were taken. and the PDH enzyme was measured in case and control groups. Results: Fifty-three percent of patients were male and the mean age of participants in case and control groups was 37. 2± 17. 3 and 34. 8± 8. 9, respectively. Subsequently, the PDH levels were measured according to the enzyme protocol. The levels of enzyme in patients with relapse were significantly lower than normal ones (P=0. 0003). The PDH serum level was also evaluated by age and sex, which did not show any significant differences (P=0. 86). Conclusion: In patients with relapsing B-cell lymphoma, the pyruvate dehydrogenase (PDH) enzyme serum levels were significantly lower than healthy subjects, but this difference was not related to age and gender. In the case of further studies and comparisons beyond this study, this enzyme could be a good candidate, used as an alternative diagnosis tool, in patients with recurrent lymphoma.

Cites

No record.

References

Prognostic role of glycolysis for cancer outcome: evidence from 86 studies

Cite

APA: Copy

HADI, ALI, MEHRZAD, VALIOLLAH, Vaziri, Nazanin, Shariati, Lalaeh, & VASEGHI, GOLNAZ. (2020). Measurement of pyruvate dehydrogenase enzyme in patients with diffuse large B-cell lymphoma relapse. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 78(2 ), 88-92. SID. https://sid.ir/paper/377287/en

Vancouver: Copy

HADI ALI, MEHRZAD VALIOLLAH, Vaziri Nazanin, Shariati Lalaeh, VASEGHI GOLNAZ. Measurement of pyruvate dehydrogenase enzyme in patients with diffuse large B-cell lymphoma relapse. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2020;78(2 ):88-92. Available from: https://sid.ir/paper/377287/en

IEEE: Copy

ALI HADI, VALIOLLAH MEHRZAD, Nazanin Vaziri, Lalaeh Shariati, and GOLNAZ VASEGHI, “Measurement of pyruvate dehydrogenase enzyme in patients with diffuse large B-cell lymphoma relapse,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 78, no. 2 , pp. 88–92, 2020, [Online]. Available: https://sid.ir/paper/377287/en

Related Journal Papers