Application of a Tocopherol in the Hepatitis B Vaccine Formulation in order to Improve Humoral and Cellular Immune Responses

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Rahimkhani A.; HAGHIGHAT S.; MAHDAVI M.

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Journal: Pathobiology Research Year:2020 | Volume:23 | Issue:3 Page(s): 129-135

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Title

Application of a Tocopherol in the Hepatitis B Vaccine Formulation in order to Improve Humoral and Cellular Immune Responses

Author(s)

Rahimkhani A. | HAGHIGHAT S. | MAHDAVI M. | Issue Writer Certificate

Keywords

hepatitis BQ3

adjuvantQ2

alumQ2

αtocopherolQ1

vitamine EQ3

Abstract

Aims: The common hepatitis B vaccination was designed based on alum adjuvant. This adjuvant is failed to stimulate cellular immunity so that, optimization is necessary for better stimulation of cellular immune responses. α--tocopherol is a key component of vitamin E that is considered as immunomodulatory agent to regulate immunity in order to decrease inflammation immune responses. Therefore, in the present study, the effect of α-tocopherol on the improvement of immune responses in hepatitis B vaccination was evaluated. Materials & Methods: commercial hepatitis B vaccine was formulated with α-tocopherol at the doses of 1, 5, and 10mg. The vaccine was injected into BALB/C mice three times two weeks apart. Ten days after the last injection, blooddrawing was performed from mice groups. The levels of IFN-γ , TNF-α , IL-4, and IL-2 cytokines and IgG total antibody, as well as IgG1 and IgG2a antibody isotypes, were measured by ELISA method. Findings: Formulated vaccine at the dose of 10mg of α-tocopherol is more potent in the significant increase of IFN-γ , TNF-α , and IL-2 cytokines and low dose result in improvement of humoral immune response. Conclusion: Immune response of vaccine formulated with α-tocopherol was dose-dependent and at the dose of 10mg demonstrated a significant increase of Th1 response and at the dose of 1mg result in increase of antibody responses.

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APA: Copy

Rahimkhani, A., HAGHIGHAT, S., & MAHDAVI, M.. (2020). Application of a Tocopherol in the Hepatitis B Vaccine Formulation in order to Improve Humoral and Cellular Immune Responses. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 23(3 ), 129-135. SID. https://sid.ir/paper/377721/en

Vancouver: Copy

Rahimkhani A., HAGHIGHAT S., MAHDAVI M.. Application of a Tocopherol in the Hepatitis B Vaccine Formulation in order to Improve Humoral and Cellular Immune Responses. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2020;23(3 ):129-135. Available from: https://sid.ir/paper/377721/en

IEEE: Copy

A. Rahimkhani, S. HAGHIGHAT, and M. MAHDAVI, “Application of a Tocopherol in the Hepatitis B Vaccine Formulation in order to Improve Humoral and Cellular Immune Responses,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 23, no. 3 , pp. 129–135, 2020, [Online]. Available: https://sid.ir/paper/377721/en

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