Investigation of Antimicrobial Effect of Berberine on Ciprofloxacin and Imipenem Resistance Acinetobacter baumannii Isolated from Hamadan Hospitals

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MAHMOUDI HASSAN; Zare Fahim Nayreh; ALIKHANI MOHAMMAD YOUSEF; SHOKOOHIZADEH LEILI

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2020 | Volume:14 | Issue:1 Page(s): 44-54

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Title

Investigation of Antimicrobial Effect of Berberine on Ciprofloxacin and Imipenem Resistance Acinetobacter baumannii Isolated from Hamadan Hospitals

Author(s)

MAHMOUDI HASSAN | Zare Fahim Nayreh | ALIKHANI MOHAMMAD YOUSEF | SHOKOOHIZADEH LEILI | Issue Writer Certificate

Keywords

Acinetobacter baumanniiQ2

CiprofloxacinQ2

ImipenemQ1

BerberineQ1

Abstract

Background: Acinetobacter baumannii is one of the causes of nosocomial infections, especially in the intensive care unit. The emergence of multidrug-resistant strains of A. baumannii has caused many problems. One of the ways to handle the phenomenon of antibiotic resistance is the use of herbal medicines and their derivatives in place of or in combination with antibiotics. The aim of this study was to investigate the effect of inhibitory effects of Berberine as a barberry derivative on clinical isolates of A. baumannii, resistant to Ciprofloxacin and Imipenem in Hamadan hospitals. Materials & Methods: In this study, 70 clinical isolates of A. baumannii. were identified and diagnosed using conventional microbiology. Resistance of isolates was detected against Imipenem and Ciprofloxacin by disk diffusion and broth microdilution method. Minimum inhibitory concentration (MIC) of Berberine as well as its combined effect with antibiotics were performed using broth microdilution method. Results: The results of this study showed that more than 90% of isolates are resistant to Ciprofloxacin and Imipenem. Imipenem and Ciprofloxacin MICs were dtermined from 8 to 28 and 4 to 32 μ g / mL, respectively. The Berberine decreased the Imipenem and Ciprofloxacin MIC from zero to two fold and zero to one-fold, respectively. Conclusion: High level resistance to Imipenem and Ciprofloxacin among A. baumannii isolates is cause of concern. Berberin, in combination with Imipenem and Ciprofloxacin, reduces MIC to a proper level, which can be used as an effective agent to reduce antibiotic resistance in bacteria.

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APA: Copy

MAHMOUDI, HASSAN, Zare Fahim, Nayreh, ALIKHANI, MOHAMMAD YOUSEF, & SHOKOOHIZADEH, LEILI. (2020). Investigation of Antimicrobial Effect of Berberine on Ciprofloxacin and Imipenem Resistance Acinetobacter baumannii Isolated from Hamadan Hospitals. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 14(1 ), 44-54. SID. https://sid.ir/paper/378942/en

Vancouver: Copy

MAHMOUDI HASSAN, Zare Fahim Nayreh, ALIKHANI MOHAMMAD YOUSEF, SHOKOOHIZADEH LEILI. Investigation of Antimicrobial Effect of Berberine on Ciprofloxacin and Imipenem Resistance Acinetobacter baumannii Isolated from Hamadan Hospitals. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2020;14(1 ):44-54. Available from: https://sid.ir/paper/378942/en

IEEE: Copy

HASSAN MAHMOUDI, Nayreh Zare Fahim, MOHAMMAD YOUSEF ALIKHANI, and LEILI SHOKOOHIZADEH, “Investigation of Antimicrobial Effect of Berberine on Ciprofloxacin and Imipenem Resistance Acinetobacter baumannii Isolated from Hamadan Hospitals,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 14, no. 1 , pp. 44–54, 2020, [Online]. Available: https://sid.ir/paper/378942/en

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