EXPRESSION OF APOPTOSIS INDUCING-IIGANDS, TRAIL AND FAS-L IN HYDATID CYST GERMINAL LAYER AND NORMAL TISSUE

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SPOTIN A.; MOKHTARI AMIRMAJDI M.; SANKIAN M.; VARASTEH A.; VAHEDI F.; SHAMSIAN A.A.

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Journal: Journal of Ardabil University of Medical Sciences Year:2012 | Volume:12 | Issue:1 (43) Page(s): 7-16

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Title

EXPRESSION OF APOPTOSIS INDUCING-IIGANDS, TRAIL AND FAS-L IN HYDATID CYST GERMINAL LAYER AND NORMAL TISSUE

Author(s)

Keywords

HYDATID CYSTQ3

APOPTOSISQ3

TRAILQ2

FAS-LQ2

Abstract

Background & objectives: Hydaticosis is a zoonotic helminthic disease of human and other intermediated hosts in which larval stages of the tapeworm Echinococcus granulosu transfect human. The liver and lung are the host tissues for the HYDATID CYST. It is unknown which mechanisms are involved in infertility of the cyst and suppression of the fertile cyst. This study was aimed to evaluate the expression of the APOPTOSIS inducing-ligands such as TRAIL and FAS-L in germinal layer of the cyst and human normal tissue surrounding the cyst that is one of the unknown host innate immunity mechanisms against the HYDATID CYST.Methods: In this study, four isolated HYDATID CYSTs were used which had been diagnosed in patients by radiography and parasitological examination in Mashhad Ghaem hospital. Furthermore, the germinal layer of the cyst and accompanied normal peripheral tissues were separated by scalpel in sterile conditions. After homogenization, expression of TRAIL and Fas- L genes were studied by semi-quantitive RT-PCR method.Results: The TRAIL and FAS-L showed significant higher level expression in germinal layer of infertile cyst than the fertile cyst and host normal tissues.Conclusion: The host tissue-induced APOPTOSIS of germinal layer of the fertile cysts is probably one of the infertility mechanisms in patients with hydaticosis.

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APA: Copy

SPOTIN, A., MOKHTARI AMIRMAJDI, M., SANKIAN, M., VARASTEH, A., VAHEDI, F., & SHAMSIAN, A.A.. (2012). EXPRESSION OF APOPTOSIS INDUCING-IIGANDS, TRAIL AND FAS-L IN HYDATID CYST GERMINAL LAYER AND NORMAL TISSUE. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), 12(1 (43)), 7-16. SID. https://sid.ir/paper/379041/en

Vancouver: Copy

SPOTIN A., MOKHTARI AMIRMAJDI M., SANKIAN M., VARASTEH A., VAHEDI F., SHAMSIAN A.A.. EXPRESSION OF APOPTOSIS INDUCING-IIGANDS, TRAIL AND FAS-L IN HYDATID CYST GERMINAL LAYER AND NORMAL TISSUE. JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS)[Internet]. 2012;12(1 (43)):7-16. Available from: https://sid.ir/paper/379041/en

IEEE: Copy

A. SPOTIN, M. MOKHTARI AMIRMAJDI, M. SANKIAN, A. VARASTEH, F. VAHEDI, and A.A. SHAMSIAN, “EXPRESSION OF APOPTOSIS INDUCING-IIGANDS, TRAIL AND FAS-L IN HYDATID CYST GERMINAL LAYER AND NORMAL TISSUE,” JOURNAL OF ARDABIL UNIVERSITY OF MEDICAL SCIENCES (JAUMS), vol. 12, no. 1 (43), pp. 7–16, 2012, [Online]. Available: https://sid.ir/paper/379041/en

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