In vitro Cytotoxicity Evaluation of Steviosid on Cancerous Liver (Hep G2), Colon (HT29), Breast (MCF7) cells and Normal Kidney Cell (Hek293) in Comparison with Cisplatin

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Abolhasani Ahmad; HEIDARI FATEMEH; Raminfar Roghayeh; Mousavi Shokoufeh; Abolhasani Hoda

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2020 | Volume:14 | Issue:3 Page(s): 26-34

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Title

In vitro Cytotoxicity Evaluation of Steviosid on Cancerous Liver (Hep G2), Colon (HT29), Breast (MCF7) cells and Normal Kidney Cell (Hek293) in Comparison with Cisplatin

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SteviosideQ1

HT29 CellsQ1

Hep G2 CellsQ1

MCF-7 CellsQ1

Hek293 CellsQ1

Abstract

Background and Objectives: Stevioside, a natural sweetener derived from Stevia plant, has anti-cancer properties. Accordingly, the present study investigated the in vitro effects of Stevioside cytotoxicity on cancerous liver (Hep G2), colon (HT29), and breast (MCF7) cells and normal human embryonic kidney cell (Hek293) compared to cisplatin as anticancer drug. Methods: In the present study, cytotoxic activity of Stevioside was investigated and compared with cisplatin as a well-known anti-cancer drug. The cytotoxic effects of Stevioside and cisplatin on Hep G2, HT29, MCF7, and Hek293 Cells, were investigated by MTT assay. IC50 values were calculated by fitting the data in a sigmoidal dose-response curve using non-linear regression analysis for each cell line. Results: Among the studied cancerous cell lines, Stevioside showed higher cell growth inhibition on Hep G2 cell line. Stevioside did not have high toxicity on Hek293 normal cell line, but cisplatin had more toxicity in comparison with steviosid on the normal human embryonic kidney cell. Conclusion: The sweetener Stevioside, showed less cytotoxic effects compared to cisplatin. Due to its non-toxicity to normal human kidney embryonic cell (Hek293), Stevioside can be used as auxiliary treatment regimen in patients with liver, breast, and colon cancers.

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APA: Copy

Abolhasani, Ahmad, HEIDARI, FATEMEH, Raminfar, Roghayeh, Mousavi, Shokoufeh, & Abolhasani, Hoda. (2020). In vitro Cytotoxicity Evaluation of Steviosid on Cancerous Liver (Hep G2), Colon (HT29), Breast (MCF7) cells and Normal Kidney Cell (Hek293) in Comparison with Cisplatin. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 14(3 ), 26-34. SID. https://sid.ir/paper/379081/en

Vancouver: Copy

Abolhasani Ahmad, HEIDARI FATEMEH, Raminfar Roghayeh, Mousavi Shokoufeh, Abolhasani Hoda. In vitro Cytotoxicity Evaluation of Steviosid on Cancerous Liver (Hep G2), Colon (HT29), Breast (MCF7) cells and Normal Kidney Cell (Hek293) in Comparison with Cisplatin. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2020;14(3 ):26-34. Available from: https://sid.ir/paper/379081/en

IEEE: Copy

Ahmad Abolhasani, FATEMEH HEIDARI, Roghayeh Raminfar, Shokoufeh Mousavi, and Hoda Abolhasani, “In vitro Cytotoxicity Evaluation of Steviosid on Cancerous Liver (Hep G2), Colon (HT29), Breast (MCF7) cells and Normal Kidney Cell (Hek293) in Comparison with Cisplatin,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 14, no. 3 , pp. 26–34, 2020, [Online]. Available: https://sid.ir/paper/379081/en

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