Effect of acute L-carnitine administration alone or combination with sodium valproate on pentylenetetrazole-induced seizures in mice

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Vaghefi Esfidani s.m.; HEYDARI A.

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Journal: Feyz Medical Sciences Journal Year:2021 | Volume:24 | Issue:6 Page(s): 592-600

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Title

Effect of acute L-carnitine administration alone or combination with sodium valproate on pentylenetetrazole-induced seizures in mice

Author(s)

Vaghefi Esfidani s.m. | HEYDARI A. | Issue Writer Certificate

Keywords

L-carnitineQ1

Sodium valproateQ2

PentylenetetrazoleQ2

SeizureQ3

EpilepsyQ2

MiceQ2

Abstract

Background: L-carnitine, as an endogenous compound, has paradoxical effects on Seizures. This study aimed to evaluate the effect of acute administration of L-carnitine alone or combination with Sodium valproate on Pentylenetetrazole (PTZ) induced myoclonic and tonic Seizure thresholds in Mice. Materials and Methods: In this study, 64 male NMRI Mice (25-30 g) were divided into 8 groups (8 animals in each group). Normal saline (as solvent), L-carnitine (50, 100, 150 and 200 mg/kg), Sodium valproate (50 and 150 mg/kg) and combination of the ineffective doses of L-carnitine/Sodium valproate (100. 50 mg/kg) were administered by gavage. L-carnitine and Sodium valproate were administrated 4 and 2 hours before Seizure induction, respectively. Intravenous infusion of PTZ was used to induce Seizure induction. All data were analyzed using a one-way analysis of variance (ANOVA) via SPSS version 21. 0 software. Results: The results showed that L-carnitine at doses of 150 and 200 mg/kg significantly increased the threshold of myoclonic and tonic Seizures compared to the control group (P<0. 01). Also, combination of the L-carnitine/Sodium valproate significantly increased the threshold for tonic Seizures compared to the ineffective dose of Sodium valproate (P=0. 007). Conclusion: The results of this study showed that acute administration of L-carnitine increases the threshold of myoclonic and tonic Seizures. Co-administration of L-carnitine with Sodium valproate significantly increases the threshold for tonic Seizures, also. This may be due to changes in the metabolism of Sodium valproate.

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APA: Copy

Vaghefi Esfidani, s.m., & HEYDARI, A.. (2021). Effect of acute L-carnitine administration alone or combination with sodium valproate on pentylenetetrazole-induced seizures in mice. FEYZ, 24(6 ), 592-600. SID. https://sid.ir/paper/380693/en

Vancouver: Copy

Vaghefi Esfidani s.m., HEYDARI A.. Effect of acute L-carnitine administration alone or combination with sodium valproate on pentylenetetrazole-induced seizures in mice. FEYZ[Internet]. 2021;24(6 ):592-600. Available from: https://sid.ir/paper/380693/en

IEEE: Copy

s.m. Vaghefi Esfidani, and A. HEYDARI, “Effect of acute L-carnitine administration alone or combination with sodium valproate on pentylenetetrazole-induced seizures in mice,” FEYZ, vol. 24, no. 6 , pp. 592–600, 2021, [Online]. Available: https://sid.ir/paper/380693/en

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