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Title

ANDROGENIC EFFECT OF ORIGANUM VULGAREL L.SPP VIRIDE EXTRACT ON HORMONE LEVEL OF PITUITARY - GONADAL AXIS IN MATURE MALE VISTAR RATS

Pages

  89-96

Keywords

LUTEINIZING STIMULATED HORMONE (LH)Q2

Abstract

 Background: ORIGANUM VULGARE l.spp viride was used in ancient medicine and it was medicated for digestive disease, diabetes, remedy of trauma. While antimicrobial, ant diabetic, anticancer and antioxidant effect of this plant was proved but there is done no study for its effect on reproductive system.Therefore the purpose of recent study is surveying eventual ANDROGENIC EFFECT of this plant on hormonal level of pituitary - gonadal axis in mature male vistar rats.Materials and Methods: recent study was done on five groups of male rats of vistar race and every group includes nine rats. The control group received no drug. The sham group received physiological serum and experimental groups of A, B and C were received the ethanolic extract of ORIGANUM VULGARE l. with concentration of 40, 20, 10 mg/kg body weight respectively with gavaj for 14 days. Then levels of FSH, LH and TSH hormones in blood sample was measured with RIA method and obtaining result was compared between control group and other groups. Data was analyzed with SPSS software and statistical method of ANOVA and Tukey test. In this research, significant level was p<0.05.Results: in control group, sham group and A, B and C groups, respectively mean and standard deviation from average of plasma concentration for LH hormone based on mlU /ml were: 0.18±0.006, 0.183±0.017, 0.187±0.026, 0.241±0.012 and 0.284±0.027 And for FSH Hormone were: 0.321±0.025, 0.342±0.071,0.372±0.026, 0.383±0.031 and 0.372±0.026 And for TSH hormone were: 5.28±0.683, 6.07±0.5, 6.09 ±1.94, 6.66±1.48 and 8.1±1.66.Conclusion: ethanolic extract of ORIGANUM VULGARE leaf in maximum dose have ANDROGENIC EFFECTs and it can affect the activity of different levels of hypothalamic-pituitary-gonadal axis and increase the secretion of TESTOSTERONE and gonadotropic hormones.

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    APA: Copy

    KAZEMI, P., JOWHARY, H., SHARIFI, E., & ZERAAT PISHEH, A.. (2011). ANDROGENIC EFFECT OF ORIGANUM VULGAREL L.SPP VIRIDE EXTRACT ON HORMONE LEVEL OF PITUITARY - GONADAL AXIS IN MATURE MALE VISTAR RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 14(6 (59)), 89-96. SID. https://sid.ir/paper/380826/en

    Vancouver: Copy

    KAZEMI P., JOWHARY H., SHARIFI E., ZERAAT PISHEH A.. ANDROGENIC EFFECT OF ORIGANUM VULGAREL L.SPP VIRIDE EXTRACT ON HORMONE LEVEL OF PITUITARY - GONADAL AXIS IN MATURE MALE VISTAR RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2011;14(6 (59)):89-96. Available from: https://sid.ir/paper/380826/en

    IEEE: Copy

    P. KAZEMI, H. JOWHARY, E. SHARIFI, and A. ZERAAT PISHEH, “ANDROGENIC EFFECT OF ORIGANUM VULGAREL L.SPP VIRIDE EXTRACT ON HORMONE LEVEL OF PITUITARY - GONADAL AXIS IN MATURE MALE VISTAR RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 14, no. 6 (59), pp. 89–96, 2011, [Online]. Available: https://sid.ir/paper/380826/en

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