Effect of combined Ondansetron and Apotel on control of the post-operative pain after surgery of upper limb fractures: A clinical trial study

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Akhondi Salehe; MEHRAVAR FATEMEH; ROKHTABNAK FARANAK; MOMEN OMID; Mojaveraghili Seyed Babak

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Journal: Journal of Gorgan University of Medical Sciences Year:2019 | Volume:21 | Issue:3 (71) Page(s): 34-40

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Title

Effect of combined Ondansetron and Apotel on control of the post-operative pain after surgery of upper limb fractures: A clinical trial study

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Keywords

SurgeryQ2

Upper limb fracturesQ2

OndansetronQ1

ApotelQ3

AcetaminophenQ2

PainQ3

General anaesthesiaQ3

Abstract

Background and Objective: Control of postoperative Pain is one of the most important stages in the recovery of patients after Surgery. This study was done to compare the effectiveness of combined Ondansetron and Apotel on the post-operative Pain after Surgery of Upper limb fractures. Methods: This double blind clinical trial study was done on 50 individual (41 male and 9 female) with Upper limb fractures referring to 5 Azar hospital in Gorgan northern Iran during 2017. Patients were assigned (block randomization) into control and intervention groups. After the end of operation in the recovery phase, both groups received Pain PCA (Patient Controlled Analgesia). In control group, the Pain pump consisted of 2 grams of Apotel and in the intervention group; the Pain pump consisted of 2 grams Apotel and 8 mg of Ondansetron. Visual Analogue Score (VAS) was evaluated in both groups after Surgery for 24 hours. Pain score of patients compared in the 2 groups during the 3 time intervals after Surgery. Results: 4 hours after upper limb fracture Surgery, the mean Pain was significantly decreased in the intervention group (3. 20± 0. 707) compared to control group (3. 64± 0. 569) (P<0. 05). 12 hours after upper limb fracture Surgery The Mean Pain, in the intervention group (1. 88± 0. 927) was significantly reduced in compare to control group (2. 64± 1. 186) (P<0. 05). 24 hours after upper limb fracture Surgery, The Mean Pain was significantly reduced in the intervention group (1. 40± 0. 645) in compare to control group (2. 08± 0. 997) (P<0. 05). Conclusion: This study showed that administration of compination of Apotele and Ondansetron in postoperative Pain of Upper limb fractures is effective than Apotele alone.

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APA: Copy

Akhondi, Salehe, MEHRAVAR, FATEMEH, ROKHTABNAK, FARANAK, MOMEN, OMID, & Mojaveraghili, Seyed Babak. (2019). Effect of combined Ondansetron and Apotel on control of the post-operative pain after surgery of upper limb fractures: A clinical trial study. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 21(3 (71) ), 34-40. SID. https://sid.ir/paper/380897/en

Vancouver: Copy

Akhondi Salehe, MEHRAVAR FATEMEH, ROKHTABNAK FARANAK, MOMEN OMID, Mojaveraghili Seyed Babak. Effect of combined Ondansetron and Apotel on control of the post-operative pain after surgery of upper limb fractures: A clinical trial study. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;21(3 (71) ):34-40. Available from: https://sid.ir/paper/380897/en

IEEE: Copy

Salehe Akhondi, FATEMEH MEHRAVAR, FARANAK ROKHTABNAK, OMID MOMEN, and Seyed Babak Mojaveraghili, “Effect of combined Ondansetron and Apotel on control of the post-operative pain after surgery of upper limb fractures: A clinical trial study,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 3 (71) , pp. 34–40, 2019, [Online]. Available: https://sid.ir/paper/380897/en

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