THE EFFECT OF METFORMIN ON UTEROPLACENTAL CIRCULATION AND PREGNANCY OUTCOMES IN PREGNANT WOMEN WITH POLYCYSTIC OVARY SYNDROME

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JAMAL ASHRAF; ALEYASIN ASHRAF; SHABANI PARISA; KHODAVERDI SEPIDEH; SHABANI ESMAT

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2010 | Volume:68 | Issue:4 Page(s): 238-241

Download Full-Text

Persian Verion

View:

1,272

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF METFORMIN ON UTEROPLACENTAL CIRCULATION AND PREGNANCY OUTCOMES IN PREGNANT WOMEN WITH POLYCYSTIC OVARY SYNDROME

Author(s)

Keywords

METFORMINQ2

POLYCYSTIC OVARY SYNDROME (PCOS)Q2

UTEROPLACENTAL CIRCULATIONQ3

Abstract

Background: Some complications of pregnancy such as abortion, gestational diabetes mellitus, preeclampsia, and preterm delivery are more common among women with polycystic ovary syndrome (PCOS). Recently it has been reported that METFORMIN treatment during pregnancy reduces pregnancy complications, so this study was conducted to demonstrate the possible effects of METFORMIN on the UTEROPLACENTAL CIRCULATION and pregnancy complications.Methods: Seventy pregnant women with polycystic ovary syndrome (PCOS) from 1386 to 1388 were enrolled in a randomized, double-blind, placebo-controlled trial of METFORMIN during pregnancy in Shariati hospital. Doppler ultrasound examinations of the uterine arteries and umbilical artery were performed at 12th and 20th weeks of gestation. All patients were followed up to the end of pregnancy, then the effect of METFORMIN on the UTEROPLACENTAL CIRCULATION was evaluated by the comparison of the pulsatility index (PI) of uterine arteries and prevalence of obstetric complications between two groups.Results: The mean reduction of PI in METFORMIN group from 12th to 20th weeks of gestation was 0.38 versus 0.16 in placebo group (p=0.016). Gestational diabetes mellitus, pre-eclampsia and preterm delivery, were more common in pregnant women in placebo group but the difference was not statistically significant.Conclusions: METFORMIN treatment in pregnancy accompanied with reduced uterine artery impedance between 12 and 20 weeks of gestation but this reduction showed no effect on the pregnancy complications such as preterm delivery, preeclampsia and gestational diabetes.

Cites

No record.

References

Cite

APA: Copy

JAMAL, ASHRAF, ALEYASIN, ASHRAF, SHABANI, PARISA, KHODAVERDI, SEPIDEH, & SHABANI, ESMAT. (2010). THE EFFECT OF METFORMIN ON UTEROPLACENTAL CIRCULATION AND PREGNANCY OUTCOMES IN PREGNANT WOMEN WITH POLYCYSTIC OVARY SYNDROME. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 68(4), 238-241. SID. https://sid.ir/paper/38100/en

Vancouver: Copy

JAMAL ASHRAF, ALEYASIN ASHRAF, SHABANI PARISA, KHODAVERDI SEPIDEH, SHABANI ESMAT. THE EFFECT OF METFORMIN ON UTEROPLACENTAL CIRCULATION AND PREGNANCY OUTCOMES IN PREGNANT WOMEN WITH POLYCYSTIC OVARY SYNDROME. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2010;68(4):238-241. Available from: https://sid.ir/paper/38100/en

IEEE: Copy

ASHRAF JAMAL, ASHRAF ALEYASIN, PARISA SHABANI, SEPIDEH KHODAVERDI, and ESMAT SHABANI, “THE EFFECT OF METFORMIN ON UTEROPLACENTAL CIRCULATION AND PREGNANCY OUTCOMES IN PREGNANT WOMEN WITH POLYCYSTIC OVARY SYNDROME,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 68, no. 4, pp. 238–241, 2010, [Online]. Available: https://sid.ir/paper/38100/en

Related Journal Papers