Molecular Structure Investigation of Gluten and Its Role in Celiac Disease

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Nadimifar Mohammad sadegh; ROSTAMI NEJAD MOHAMMAD; HABIBI REZAEI MEHRAN; ZALI MOHAMMAD REZA; MOOSAVI MOVAHEDI ALI AKBAR

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Journal: GOVARESH JOURNAL Year:2020 | Volume:25 | Issue:3 Page(s): 171-178

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Title

Molecular Structure Investigation of Gluten and Its Role in Celiac Disease

Author(s)

Keywords

Celiac DiseaseQ2

GlutenQ2

GliadinQ1

Glutamic AcidQ1

Trans-GlutamineaseQ1

HLA-DQ2Q1

Abstract

Coeliac disease, or celiac sprue, is an autoimmune disorder of the small intestine with a genetic background. As a result of immunological responses to Gluten consumption, small bowel villi will have damaged and cause malabsorption of nutrients. The symptoms of this disorder appeared due to presence of Gluten, a stored protein in the endosperm of grains such as wheat, barley and rye in the patient’ s diet. Gluten made up of two protein components called Gliadin and glutinine. An alcohol-soluble component, Gliadin, is the main cause of Coeliac disease symptoms. The "N" terminal of Gliadin usually has repetitive sequence rich in glutamine, proline, phenylalanine, and tyrosine. Due to the mechanism of Coeliac disease, Trans-Glutaminease and Glutamic Acid in the N terminal of Gluten are played very important role. On the other hand, a human leukocyte antigen, HLA-DQ2, as an internal factor, plays a major role in the immunological response. In this study, in addition to introducing the mechanism of Celiac Disease, the molecular structure of Gluten and it interacts with HLA-DQ2 will be reviewed.

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APA: Copy

Nadimifar, Mohammad sadegh, ROSTAMI NEJAD, MOHAMMAD, HABIBI REZAEI, MEHRAN, ZALI, MOHAMMAD REZA, & MOOSAVI MOVAHEDI, ALI AKBAR. (2020). Molecular Structure Investigation of Gluten and Its Role in Celiac Disease. GOVARESH JOURNAL, 25(3 ), 171-178. SID. https://sid.ir/paper/381377/en

Vancouver: Copy

Nadimifar Mohammad sadegh, ROSTAMI NEJAD MOHAMMAD, HABIBI REZAEI MEHRAN, ZALI MOHAMMAD REZA, MOOSAVI MOVAHEDI ALI AKBAR. Molecular Structure Investigation of Gluten and Its Role in Celiac Disease. GOVARESH JOURNAL[Internet]. 2020;25(3 ):171-178. Available from: https://sid.ir/paper/381377/en

IEEE: Copy

Mohammad sadegh Nadimifar, MOHAMMAD ROSTAMI NEJAD, MEHRAN HABIBI REZAEI, MOHAMMAD REZA ZALI, and ALI AKBAR MOOSAVI MOVAHEDI, “Molecular Structure Investigation of Gluten and Its Role in Celiac Disease,” GOVARESH JOURNAL, vol. 25, no. 3 , pp. 171–178, 2020, [Online]. Available: https://sid.ir/paper/381377/en

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