DETERMINING THE RELATION OF DIALYSIS TYPE WITH PLASMA HOMOCYSTEINE LEVEL IN PATIENTS WITH END STAGE RENAL DISEASE

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SICAROODI H.; FATHI D.; LOTFT J.; ALA ALDINI F.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2004 | Volume:62 | Issue:5 Page(s): 423-431

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Title

DETERMINING THE RELATION OF DIALYSIS TYPE WITH PLASMA HOMOCYSTEINE LEVEL IN PATIENTS WITH END STAGE RENAL DISEASE

Author(s)

SICAROODI H. | FATHI D. | LOTFT J. | ALA ALDINI F. | Issue Writer Certificate

Keywords

ND STAGE RENAL DISEASEQ4

DIALYSIS TYPEQ4

HOMOCYSTEINEQ4

Abstract

Background: Acute coronary events are the main cause of death in patients with eND STAGE RENAL DISEASE (ESRD). A large series of cross-sectional and retrospective studies indicate a positive relationship between mild and moderate hyperhomocysteinemia and atherosclerosis. It has been determined that the plasma HOMOCYSTEINE level in patients with ESRD is high. However, a few studies have been done to determine the effect of DIALYSIS TYPE on the plasma HOMOCYSTEINE level.Materials and Methods: In this analytic cross-sectional study, 120 patients with ESRD were examined. Among them, two groups of twenty-two patients who were undergoing hemodialysis or peritoneal dialysis were randomly elected. The members of each group had been matched according to their age, sex and the quality of dialysis (KTN). The plasma HOMOCYSTEINE level was measured in each group. Accordingly, the effect of DIALYSIS TYPE on the plasma HOMOCYSTEINE level was analyzed.Results: The mean plasma HOMOCYSTEINE level of all samples taken was 16.2 ± 8.7 μmol/L. It was 17.95 ± 10 μmollL and 13.2 ± 5.3μLmol/L in patients who were undergoing hemodialysis and peritoneal dialysis respectively. The mean of the differences in the plasma HOMOCYSTEINE levels from the matched pairs was 4.37±11.34μLmol/L (p=0.064). In addition, there was not any relation between the plasma HOMOCYSTEINE level and serum creatinine level or duration of dialysis. Conclusion: There is not any significant relation (p=0.064) between the plasma HOMOCYSTEINE level and the type of dialysis of patients with ESRD. Nevertheless, in this study, the mean HOMOCYSTEINE level in the patients who were undergoing hemodialysis was higher than in the patients who were being treated with peritoneal dialysis. In conclusion, none of two current kinds of dialysis have any advantage over the other in decreasing plasma HOMOCYSTEINE level in patients with ESRD.

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