Protective Effect of N-acetyl-cysteine Against Rat Liver Mitochondrial Toxicity Induced by CuSO4

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RAHMANI SOHRAB; REZAEI MOHSEN

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2020 | Volume:14 | Issue:6 Page(s): 9-17

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Title

Protective Effect of N-acetyl-cysteine Against Rat Liver Mitochondrial Toxicity Induced by CuSO4

Author(s)

RAHMANI SOHRAB | REZAEI MOHSEN | Issue Writer Certificate

Keywords

AcetylcysteineQ1

Barth syndromeQ1

CuSO4Q1

GlutathioneQ2

Abstract

Background and Objectives: Copper sulfate (CuSO4) is a toxic substance with a broad range of applications; however, the ingestion of high levels of it cause a wide range of complications in the liver tissue. According to previous studies, mitochondria are potential targets for CuSO4 toxicity. The present study aimed to examine the role of Nacetyl-cysteine as an antioxidant agent in the protection of mitochondria against toxicity induced by CuSO4. Methods: This study was performed on isolated liver mitochondria extracted from male Wistar rats (180-200 g) by multiple centrifuges and finally divided into 5 different groups. Group 1 was the control group, while group 2 received a single dose of 106 µ M of CuSO4. The other groups were pretreated with different concentrations of N-Acetylcysteine (1, 2, 5 mM) and exposed to 106 µ M of CuSO4. Subsequently, MTT assay, lipid peroxidation, and GSH (reduced Glutathione) were determined in each group. Finally, the collected data were analyzed using the one-way analysis of variance test. Results: The results of the present study revealed that significant changes in mitochondrial indexes such as mitochondrial complex Ⅱ function, mitochondrial Glutathione reduction, and lipid peroxidation levels were evident in rat liver mitochondria exposed to CuSO4. On the other hand, it was found that pre-treatment with N-Acetylcysteine efficiently inhibited CuSO4 toxicity. Conclusion: The results confirmed the protective effects of N-Acetylcysteine against CuSO4 toxicity on rat liver mitochondria, which may be due to its ability to scavenge reactive oxygen species.

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APA: Copy

RAHMANI, SOHRAB, & REZAEI, MOHSEN. (2020). Protective Effect of N-acetyl-cysteine Against Rat Liver Mitochondrial Toxicity Induced by CuSO4. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 14(6 ), 9-17. SID. https://sid.ir/paper/381847/en

Vancouver: Copy

RAHMANI SOHRAB, REZAEI MOHSEN. Protective Effect of N-acetyl-cysteine Against Rat Liver Mitochondrial Toxicity Induced by CuSO4. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2020;14(6 ):9-17. Available from: https://sid.ir/paper/381847/en

IEEE: Copy

SOHRAB RAHMANI, and MOHSEN REZAEI, “Protective Effect of N-acetyl-cysteine Against Rat Liver Mitochondrial Toxicity Induced by CuSO4,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 14, no. 6 , pp. 9–17, 2020, [Online]. Available: https://sid.ir/paper/381847/en

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