EVALUATION OF SPERM QUALITY, MATURATION AND DNA INTEGRITY IN ADULT MICE TREATED WITH SULPIRIDE

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AHMADI ARAM; SADER KHANLOU RAJAB ALI; SALAMI SIAMAK; AHMADI ABBAS

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Journal: Tehran University Medical Journal Year:2012 | Volume:70 | Issue:4 Page(s): 205-211

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Title

EVALUATION OF SPERM QUALITY, MATURATION AND DNA INTEGRITY IN ADULT MICE TREATED WITH SULPIRIDE

Author(s)

AHMADI ARAM | SADER KHANLOU RAJAB ALI | SALAMI SIAMAK | AHMADI ABBAS | Issue Writer Certificate

Keywords

DNA DAMAGEQ2

NUCLEAR MATURATIONQ2

SPERM QUALITYQ2

SULPIRIDEQ2

Abstract

Background: Use of certain antipsychotic drugs has severe effects on fertility in males.Hypothalamus and hypophysial impressions and changes in plasma hormones concentration like prolactin, LH and FSH can affect sperm production. In this study, we investigated the effects of SULPIRIDE on SPERM QUALITY, maturation and DNA DAMAGE.Methods: Twenty for adult male mice (age: 6-8 weeks) were divided into three groups.The treatment group received 40 mg/kg SULPIRIDE solution and the control sham group was given carrier of the drug intraperitoneally (IP) daily for 45 days but the control group received nothing. Finally, all the mice were sacrificed by cervical dislocation and their cauda epididymis were removed surgically. The excised specimens were placed in 1 ml HTF medium and incubated for 30 min in CO2 incubator to allow the spermatozoa to swim out. Later, sperm count, motility and viability were analyzed. Additionally, sperm chromatin quality and DNA integrity were assessed by aniline blue and acridine orange staining.Results: Significant decrease in sperm motility and count were observed in the treatment group while the number of abnormal sperm increased as compared with the other two groups. Sperm viability and DNA maturation showed significant reduction and the rate of DNA DAMAGE increased in comparison with the control sham and the control groups (P<0.05).Conclusion: The study showed that SULPIRIDE has negative effects on sperm parameters in treated animals and in some cases it could cause secondary infertility.

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APA: Copy

AHMADI, ARAM, SADER KHANLOU, RAJAB ALI, SALAMI, SIAMAK, & AHMADI, ABBAS. (2012). EVALUATION OF SPERM QUALITY, MATURATION AND DNA INTEGRITY IN ADULT MICE TREATED WITH SULPIRIDE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 70(4), 205-211. SID. https://sid.ir/paper/38193/en

Vancouver: Copy

AHMADI ARAM, SADER KHANLOU RAJAB ALI, SALAMI SIAMAK, AHMADI ABBAS. EVALUATION OF SPERM QUALITY, MATURATION AND DNA INTEGRITY IN ADULT MICE TREATED WITH SULPIRIDE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2012;70(4):205-211. Available from: https://sid.ir/paper/38193/en

IEEE: Copy

ARAM AHMADI, RAJAB ALI SADER KHANLOU, SIAMAK SALAMI, and ABBAS AHMADI, “EVALUATION OF SPERM QUALITY, MATURATION AND DNA INTEGRITY IN ADULT MICE TREATED WITH SULPIRIDE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 70, no. 4, pp. 205–211, 2012, [Online]. Available: https://sid.ir/paper/38193/en

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