INFLUENCE OF GNRH ANALOGUE ON BODY MASS INDEX IN GIRLS WITH PRECOCIOUS PUBERTY: A PROSPECTIVE STUDY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOAYERI HESHMAT; MODARRESI MOSALLA ZEINAB; SHARIAT MAMAK; HAGHSHENAS ZAHRA; NADERI FARIBA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2014 | Volume:72 | Issue:3 Page(s): 174-180

Download Full-Text

Persian Verion

View:

1,243

Download:

Cites:

Information Journal Paper

Title

INFLUENCE OF GNRH ANALOGUE ON BODY MASS INDEX IN GIRLS WITH PRECOCIOUS PUBERTY: A PROSPECTIVE STUDY

Author(s)

Keywords

BODY MASS INDEXQ3

GNRH AGONISTQ2

OBESITYQ2

PRECOCIOUS PUBERTYQ2

Abstract

Background: Gonadotropin-releasing hormone analog (GnRHa) therapy is used in central PRECOCIOUS PUBERTY (CPP) worldwide and it is the treatment of choice for this condition. Many of the previous studies concerning the effect of gonadotropin-releasing hormone analog (GnRHa) therapy on height. Much less attention has been paid to changes in body weight. However, concerns have been expressed that CPP may be associated with increased BODY MASS INDEX (BMI) both at initial presentation and during GNRH AGONIST treatment, but it is controversial in some studies.Methods: We have retrospectively reviewed 52 female patients that the majority of them had CPP. We assessed height, height SDS, weight, weight SDS, BMI and BMI SDS. All patients were treated with GnRHa over 12 months. The variables were evaluated at 0, 6 and 12 months after initiation of treatment.8 girls received growth hormone concomitantly. Also bone age and sexual maturity were measured. Bone age was assessed according to the Greulich-Pyle method and sexual maturation was classified according to the Marshall-Tanner method.Results: Before the initiation of therapy, the girls had a mean BMI SD score for chronological age of 0.80±1.18 after 6 months of therapy BMI SDS was 0.82±1.15 and after 12 months was 0.82±1.28 the P value is 0.909 and it is not statistically significant. Height SD score for chronological age was 0.41±1.65 before the initiation of therapy and was 0.41±1.65 after 6 months and 0.43±1.60 after 12 months of therapy. The P=0.66 and it is not statistically significant. Eight girls received growth hormone concomitantly, in this group increasing height SDS is statistically significant P=0.044 but increasing BMI SDS is not significant.Conclusion: Gonadotropin-releasing hormone analog (GnRHa) therapy in central PRECOCIOUS PUBERTY (CPP) is safe for BMI and increasing of BMI is not significant, long- term follow-up study is required to elucidate whether GnRHa treatment affects adult OBESITY. Using growth hormone concomitantly, the effect on increasing height is significant.

Cites

No record.

References

Cite

APA: Copy

MOAYERI, HESHMAT, MODARRESI MOSALLA, ZEINAB, SHARIAT, MAMAK, HAGHSHENAS, ZAHRA, & NADERI, FARIBA. (2014). INFLUENCE OF GNRH ANALOGUE ON BODY MASS INDEX IN GIRLS WITH PRECOCIOUS PUBERTY: A PROSPECTIVE STUDY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 72(3), 174-180. SID. https://sid.ir/paper/38211/en

Vancouver: Copy

MOAYERI HESHMAT, MODARRESI MOSALLA ZEINAB, SHARIAT MAMAK, HAGHSHENAS ZAHRA, NADERI FARIBA. INFLUENCE OF GNRH ANALOGUE ON BODY MASS INDEX IN GIRLS WITH PRECOCIOUS PUBERTY: A PROSPECTIVE STUDY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2014;72(3):174-180. Available from: https://sid.ir/paper/38211/en

IEEE: Copy

HESHMAT MOAYERI, ZEINAB MODARRESI MOSALLA, MAMAK SHARIAT, ZAHRA HAGHSHENAS, and FARIBA NADERI, “INFLUENCE OF GNRH ANALOGUE ON BODY MASS INDEX IN GIRLS WITH PRECOCIOUS PUBERTY: A PROSPECTIVE STUDY,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 72, no. 3, pp. 174–180, 2014, [Online]. Available: https://sid.ir/paper/38211/en

Related Journal Papers