ADVANCES IN ADIPOSE-DERIVED STEM CELLS AND CARTILAGE REGENERATION: REVIEW ARTICLE

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SHEYKHHASAN MOHSEN; GHIASI MAHDIEH SADAT

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2018 | Volume:76 | Issue:5 Page(s): 295-303

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Information Journal Paper

Title

ADVANCES IN ADIPOSE-DERIVED STEM CELLS AND CARTILAGE REGENERATION: REVIEW ARTICLE

Author(s)

SHEYKHHASAN MOHSEN | GHIASI MAHDIEH SADAT | Issue Writer Certificate

Keywords

CHONDROGENESISQ1

STEM CELLSQ2

TISSUE SCAFFOLDSQ1

Abstract

The cartilage is a connective tissue that, due to the strength of its extracellular matrix, allows the tissue to tolerate mechanical stress without undergoing permanent deformation. It is responsible for the support of soft tissues and due to its smooth surface and elasticity, gives the joints the ability to slip and bend. excessive weight, excessive activity, or traumacan all cause cartilage to injury. The injury can lead to swelling, pain and varying degreesof mobility loss. The process of repairing musculoskeletal (orthopedic) injuries has led toproblems in the medical field, which can be attributed to the inherent weakness of adultcartilage tissue. Therefore, this necessitates research focused on the development of a newrestructuring strategy by combining chondrocytes or STEM CELLS with scaffolds and growthfactors to address these problems. Correspondingly, the recent tissue engineering strategiesstrongly support the simultaneous use of STEM CELLS, scaffolds and growth factors. Ithas also been observed that due to the relatively low proliferation of transplanted chondrocytes, new cartilage models construction have examined the use of adipose-derivedstem cells. Mature adipose tissue is produced as an important source of multi-functionalstem cells that can be easily separated from the stromal vascular fraction (SVF) by adiposeliposuction digestion. The adipose-derived STEM CELLS are easily accessible withoutany serious complications and have the power to differentiate into several cell lines, includingchondrocytes as well as, they evidence self-renewal when trapped in gel scaffoldssuch as collagen. Also, recent studies demonstrate some of the mechanisms involved inthe process of making cartilage of adipose-derived STEM CELLS in vitro and their restorativeability in bio-engineered scaffolds in the presence of growth factors. In addition, the importantrole of non-encoding mRNA molecules (miRNAs) has been identified in the processof chondrogenic differentiation of adipose-derived STEM CELLS. Furthermore, in severalstudies, the effect of several miRNAs has been confirmed on the regulation of the cartilagedifferentiation of the adipose-derived STEM CELLS and has also been associated witheffective results. In this article, we will present an overview of the advance in adiposederivedstem cells application in cartilage regeneration.

Cites

Application of scaffolds in cartilage tissue engineering: a review paper

References

COMBINED TREATMENT WITH PLATELET-RICH PLASMA AND INSULIN FAVOURS CHONDROGENIC AND OSTEOGENIC DIFFERENTIATION OF HUMAN ADIPOSE-DERIVED STEM CELLS IN THREE-DIMENSIONAL COLLAGEN SCAFFOLDS

Cite

APA: Copy

SHEYKHHASAN, MOHSEN, & GHIASI, MAHDIEH SADAT. (2018). ADVANCES IN ADIPOSE-DERIVED STEM CELLS AND CARTILAGE REGENERATION: REVIEW ARTICLE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 76(5 ), 295-303. SID. https://sid.ir/paper/38221/en

Vancouver: Copy

SHEYKHHASAN MOHSEN, GHIASI MAHDIEH SADAT. ADVANCES IN ADIPOSE-DERIVED STEM CELLS AND CARTILAGE REGENERATION: REVIEW ARTICLE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2018;76(5 ):295-303. Available from: https://sid.ir/paper/38221/en

IEEE: Copy

MOHSEN SHEYKHHASAN, and MAHDIEH SADAT GHIASI, “ADVANCES IN ADIPOSE-DERIVED STEM CELLS AND CARTILAGE REGENERATION: REVIEW ARTICLE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 76, no. 5 , pp. 295–303, 2018, [Online]. Available: https://sid.ir/paper/38221/en

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