DETERMINATION OF CMV INFECTION IN CSF OF CHILDREN WITH MENINGOENCEPHALITIS: PCR METHOD

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NOURBAKHSH SAMILEH; TABATABAEI AZARDOKHT; PARVARESH M.; TONEKABONI H.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2009 | Volume:66 | Issue:10 Page(s): 734-739

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Title

DETERMINATION OF CMV INFECTION IN CSF OF CHILDREN WITH MENINGOENCEPHALITIS: PCR METHOD

Author(s)

NOURBAKHSH SAMILEH | TABATABAEI AZARDOKHT | PARVARESH M. | TONEKABONI H. | Issue Writer Certificate

Keywords

PCR (POLYMERASE CHANGE REACTION)Q3

CYTOMEGALOVIRUS (CMV)Q3

MENINGOENCEPHALITISQ3

Abstract

Background: In recent years, many ill cases with cytomegalovirus reactivation in nonimmuno compromised persons reported. Goal of study: to determine the CMV infection in cerebrospinal fluid of aseptic MENINGOENCEPHALITIS children hospitalized in Rasul & Mofid hospital (2005-2007).Methods: In a cross sectional study 132 cases selected with simple sampling. CMVDNA in their Cerebro spinal fluids searched by qualitative PCR.Results: The age range of the study patients was 5 month- 13 years, median age= 2±3.7 years; 87(65.9%) male and 45 (34.1%) was female. The presenting signs and symptoms were convulsion 77(69.4%); meningitis 25 (18.8%), loss of consciousness 47(37%); neurologic defects 15.9%. DNA extrated in 11 cases. Mycoplasma- DNA in 2cases; DNA-CMV detected 2(1.5%). Positive DNA HSV found in 7(15.3%) of patients. DNAHSV type- 15.3% (7/132) cases. An infant 5 month age with developmental delay, microcephaly and recurrent convulsions. A 1 year girl with brain atrophy and progressive hydrocephaly with intracranial shunt.Conclusions: Differentiation between herpes MENINGOENCEPHALITIS and other encephalopathy based on clinical signs in children is too difficult. CMV (1.5%) has lower rate than herpes simplex type-1 (5.7%). In addition to CMV and HSV1 all of herpes family viruses (varicella, herpes 6, 7, Epstein barr virus) could have role in children with MENINGOENCEPHALITIS. In recent years a sensitive, rapid, simple diagnostic test "Single tube Multiplex PCR" in cerebro spinal fluid recommend. Rapid diagnosis and faster treatment is necessary for decreasing mortality and morbidity in all of herpes MENINGOENCEPHALITIS cases.

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APA: Copy

NOURBAKHSH, SAMILEH, TABATABAEI, AZARDOKHT, PARVARESH, M., & TONEKABONI, H.. (2009). DETERMINATION OF CMV INFECTION IN CSF OF CHILDREN WITH MENINGOENCEPHALITIS: PCR METHOD. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 66(10), 734-739. SID. https://sid.ir/paper/38240/en

Vancouver: Copy

NOURBAKHSH SAMILEH, TABATABAEI AZARDOKHT, PARVARESH M., TONEKABONI H.. DETERMINATION OF CMV INFECTION IN CSF OF CHILDREN WITH MENINGOENCEPHALITIS: PCR METHOD. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2009;66(10):734-739. Available from: https://sid.ir/paper/38240/en

IEEE: Copy

SAMILEH NOURBAKHSH, AZARDOKHT TABATABAEI, M. PARVARESH, and H. TONEKABONI, “DETERMINATION OF CMV INFECTION IN CSF OF CHILDREN WITH MENINGOENCEPHALITIS: PCR METHOD,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 66, no. 10, pp. 734–739, 2009, [Online]. Available: https://sid.ir/paper/38240/en

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