COMPARISON OF EFFECTS OF AUTOTRANSFUSION AND TRANEXAMIC ACID ON POST RDIOPULMONARY BYPASS BLEEDING

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MEHRAEIN A.; DAVOUDI S.; MADANI GIVI M.

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2004 | Volume:61 | Issue:6 Page(s): 450-456

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Title

COMPARISON OF EFFECTS OF AUTOTRANSFUSION AND TRANEXAMIC ACID ON POST RDIOPULMONARY BYPASS BLEEDING

Author(s)

MEHRAEIN A. | DAVOUDI S. | MADANI GIVI M. | Issue Writer Certificate

Keywords

AUTO TRANSFUSIONQ4

TRANEXAMIC ACIDQ4

CARDIOPULMONARY BYPASSQ4

POSTOPERATIVE BLEEDINGQ4

Abstract

Background: The aim of this study was to compare the effects of intraoperative autotransfusion and TRANEXAMIC ACID on post-operative bleeding and need for allogeneic transfusion. Materials and Methods: In a prospective, randomized study, 200 patients undergoing CABG allocated into two groups: □ AT group = 100patientsreceived1-2units (300-450cc) autologousbloodafter termination of CPB □ TX group = 100patientsreceivedtranexamicacid, 15mglkgbeforethe injection of heparin and 15mglkg after protamin injection POSTOPERATIVE BLEEDING, transfusions, complications, ICD stay and hospital stay were recorded. Results: The POSTOPERATIVE BLEEDING was lower in TX group (600 ml) than in AT group (1100 ml) (P <0.001). The rates of transfused patients in AT and TX groups were 72% and 65%. Patients in the AT group received more whole blood (2.82 units per patient vs. 1.93 units in TX group) (P<0.01). The numbers of FFP units administered per atient in AT and TX groups were 3.08 and 2.38 (P <0.01). In TX group, ICU stays and ospital stays were 0.8, 5.4 days (vs. 1.2s, 6.7 days in AT group). In AT group, there were 2 transient renal dysfunctions and two re-operations. There was no difference between all groups regarding to neurological dysfunction and coagulopathy. There is no hospital mortality in all groups. Conclusion: TRANEXAMIC ACID in comparison with intra-operative autotransfusion effectively reduces postoperative complications and allogeneic transfusions in CABG. In addition this technique due to shorter ICD and hospital stay is cost- effective.

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APA: Copy

MEHRAEIN, A., DAVOUDI, S., & MADANI GIVI, M.. (2004). COMPARISON OF EFFECTS OF AUTOTRANSFUSION AND TRANEXAMIC ACID ON POST RDIOPULMONARY BYPASS BLEEDING. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 61(6), 450-456. SID. https://sid.ir/paper/38251/en

Vancouver: Copy

MEHRAEIN A., DAVOUDI S., MADANI GIVI M.. COMPARISON OF EFFECTS OF AUTOTRANSFUSION AND TRANEXAMIC ACID ON POST RDIOPULMONARY BYPASS BLEEDING. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2004;61(6):450-456. Available from: https://sid.ir/paper/38251/en

IEEE: Copy

A. MEHRAEIN, S. DAVOUDI, and M. MADANI GIVI, “COMPARISON OF EFFECTS OF AUTOTRANSFUSION AND TRANEXAMIC ACID ON POST RDIOPULMONARY BYPASS BLEEDING,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 61, no. 6, pp. 450–456, 2004, [Online]. Available: https://sid.ir/paper/38251/en

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