THE OPTIMAL TIME OF ADJUVANT RADIATION THERAPY IN LOCOREGIONAL BREAST CANCER

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MOHAMMADIANPANAH M.; OMIDVARI SH.; AHMADLOU N.; SALABIAN M.J.; MOSALAEI A.

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2004 | Volume:2 | Issue:4 Page(s): 38-46

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Title

THE OPTIMAL TIME OF ADJUVANT RADIATION THERAPY IN LOCOREGIONAL BREAST CANCER

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Keywords

BREAST CANCERQ2

CHEMOTHERAPYQ3

TIMING OF ADJUVANT RADIATION THERAPYQ4

SEQUENCINGQ4

Abstract

Background: The optimal time and sequence of adjuvant radiation therapy and CHEMOTHERAPY after breast surgery is controversial. Radiation therapy is the most effective method for preventing locoregional recurrence following primary surgery for invasive BREAST CANCER. Delay in radiation therapy after surgery can lead to increased local recurrence and delay in CHEMOTHERAPY after surgery is associated with an increasing rate of failure in the systemic control of BREAST CANCER. This study was undertaken to determine the optimal SEQUENCING of adjuvant CHEMOTHERAPY and radiotherapy for patients with locoregional BREAST CANCER after modified radical mastectomy. Additionally, this study aimed at determining the possible effect of time of radiotherapy on local and distant cancer control and the overall survival in these patients. Patients and Methods: Over a 2.5 year period, 100 patients received CHEMOTHERAPY and radiation herapy for a locoloregional BREAST CANCER after modified radical mastectomy. The population was randomly divided into two equal groups based on the timing of radiation treatment. Fifty patients (Group I) began their radiation after completion of CHEMOTHERAPY and about 21 weeks after surgery. Group II began their radiation therapy about 3 weeks after surgery in combination with CHEMOTHERAPY. Results: There was no statistically significant difference between the two groups with respect to nodal status, stage of BREAST CANCER, age, sex and type of surgery performed. Comparison of local and distant failure and overall survival rate between the delayed radiation group (Group I), and early radiation group (Group II) was not significant. Conclusion: In patients who require both CHEMOTHERAPY and radiation therapy for a localoregional BREAST CANCER, a delay in the initiation of radiotherapy for completion of adjuvant CHEMOTHERAPY appears safe and may be preferable in patients with high risk of dissemination.

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APA: Copy

MOHAMMADIANPANAH, M., OMIDVARI, SH., AHMADLOU, N., SALABIAN, M.J., & MOSALAEI, A.. (2004). THE OPTIMAL TIME OF ADJUVANT RADIATION THERAPY IN LOCOREGIONAL BREAST CANCER. JOURNAL OF MEDICAL RESEARCH (JMR), 2(4), 38-46. SID. https://sid.ir/paper/382560/en

Vancouver: Copy

MOHAMMADIANPANAH M., OMIDVARI SH., AHMADLOU N., SALABIAN M.J., MOSALAEI A.. THE OPTIMAL TIME OF ADJUVANT RADIATION THERAPY IN LOCOREGIONAL BREAST CANCER. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2004;2(4):38-46. Available from: https://sid.ir/paper/382560/en

IEEE: Copy

M. MOHAMMADIANPANAH, SH. OMIDVARI, N. AHMADLOU, M.J. SALABIAN, and A. MOSALAEI, “THE OPTIMAL TIME OF ADJUVANT RADIATION THERAPY IN LOCOREGIONAL BREAST CANCER,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 2, no. 4, pp. 38–46, 2004, [Online]. Available: https://sid.ir/paper/382560/en

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