PULMONARY INFECTION IN RENAL TRANSPLANT RECIPIENTS IMAM KHOMEINI HOSPITAL OF TEHRAN JULY 2001-JULY 2002)

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RASOULINEZHAD MEHRNAZ; HOSSAMI H.; MAHDAVI MAZDEH M.; HAJI ABD ALBAGHI MAHBOUBEH; AHMADI F.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2004 | Volume:61 | Issue:6 Page(s): 484-489

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Title

PULMONARY INFECTION IN RENAL TRANSPLANT RECIPIENTS IMAM KHOMEINI HOSPITAL OF TEHRAN JULY 2001-JULY 2002)

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Keywords

RENAL TRANSPLANTATIONQ4

PULMONARY INFECTIONQ4

TUBERCULOSISQ4

Abstract

Background: RENAL TRANSPLANTATION is ideal treatment of chronic renal failure. PULMONARY INFECTION is a common and serious post transplant infection requiring hospitalization and is associated with high mortality. Increased susceptibility to infection is due to a decrease in the patients' immunological response caused by immunosuppression through drug administration, and by other influences. Materials and Methods: This study was case series and prospective, from July 2001 to July 2002 in Imam Khomeini hospital of Tehran. Results: 164 renal transplant recipients were studied, 14 patients (8.5%) had PULMONARY INFECTION, 11 of them (78.6%) were female and 3 (21.4%) were male. The mean age of them was 42.6 years. The patients were followed up for 9 to 12 months. All patients were on triple immunosuppressive regimens. The interval between transplantation and the appearance of pneumonia was 2 months to 10 years. The time of beginning infection in 3 cases (21.4%) was between 1 to 6 months post transplantation, 11 cases (78.6%) were occurred beyond 6 months after transplantation. In 7 cases (50%), PULMONARY INFECTION was occurred during first year after transplantation. None of the 14 patients developed PULMONARY INFECTION in first month after transplantation. BAL were used in 6 cases (42.8%) of PULMONARY INFECTION, and organism were detected in 5 of them (83.3%). The most common clinical feature was fever. Six cases were due to mycobacterium TUBERCULOSIS (42.9%), this organism was the most common ethiology of pneumonia. In this study TUBERCULOSIS was seen in 3.6% of renal transplant recipients. One patient had pulmonary mucormycosis. All patients with pulmonary TB were cured, and other cases with unknown case, were cured with empirical treatment. Conclusion: Our finding indicate the invasive diagnostic procedures are required in order to earlier and reliable diagnosis and then better outcome of transplantation.

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