COMPARISON OF GABAPENTIN, PREGABALIN AND PLACEBO AS PREMEDICATION FOR ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

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MAHOORI ALIREZA; HASSANI EBRAHIM; KARAMI NAZLI; AZIZPOURE MEHRDAD

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2017 | Volume:75 | Issue:5 Page(s): 367-373

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Title

COMPARISON OF GABAPENTIN, PREGABALIN AND PLACEBO AS PREMEDICATION FOR ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Author(s)

MAHOORI ALIREZA | HASSANI EBRAHIM | KARAMI NAZLI | AZIZPOURE MEHRDAD | Issue Writer Certificate

Keywords

CLINICAL TRIALQ3

GABAPENTINQ2

LARYNGOSCOPYQ3

PREGABALINQ3

PREMEDICATIONQ2

TRACHEAL INTUBATIONQ1

Abstract

Background: TRACHEAL INTUBATION and direct LARYNGOSCOPY are powerful noxious stimuli that can elicit sever hemodynamic responses. These hemodynamic responses should be attenuated by appropriate use of PREMEDICATION, smooth induction of anesthesia and rapid TRACHEAL INTUBATION. GABAPENTIN and PREGABALIN have been suggested in several studies to be efficient. GABAPENTIN is an antiepileptic drug and a structural analogue of gamma-Aminobutyric acid (GABA) but it does not act through GABA receptors and PREGABALIN, is also an antiepileptic agent. The aim of this study was to compare the effect of GABAPENTIN and PREGABALIN as PREMEDICATION for attenuation of hemodynamic response to LARYNGOSCOPY and endotracheal intubation.Methods: In a prospective double blinded randomized CLINICAL TRIAL, during April 2015 to March 2016 in Urmia Imam Khomeini Hospital, a total of ninety normotensive adult consented patients, candidate to elective abdominal surgery aged 20-50 years, American Society of Anesthesiologist (ASA) class I, of both gender were randomized into three groups. Patients in group I received oral placebo, group II received oral GABAPENTIN 900 mg and group III patients received oral PREGABALIN 150 mg two hours prior to induction of anesthesia. Anesthetic technique was same in three groups and all groups were assessed for hemodynamic changes such as heart rate, systolic blood pressure and diastolic blood pressure, after the PREMEDICATION, before and after induction of anesthesia, and 1, 3 and 5 minutes. after LARYNGOSCOPY and TRACHEAL INTUBATION.Results: Significant increase in heart rate and systolic blood pressure and diastolic arterial pressure was observed in placebo group after TRACHEAL INTUBATION, while statistically significant attenuation of hemodynamic changes was seen in GABAPENTIN and PREGABALIN groups. (P=0.001) No adverse outcome was reported in the study groups.Conclusion: Oral GABAPENTIN PREMEDICATION is effective for control of hemodynamic pressor response of LARYNGOSCOPY and TRACHEAL INTUBATION. The study data showed that the PREGABALIN have the same effect. PREGABALIN and GABAPENTIN are both useful and safe for control of hemodynamic pressor response as PREMEDICATION.

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References

THE EFFECT OF LOW-DOSE REMIFENTANIL ON THE HEMODYNAMIC RESPONSES OF ENDOTRACHEAL EXTUBATION

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APA: Copy

MAHOORI, ALIREZA, HASSANI, EBRAHIM, KARAMI, NAZLI, & AZIZPOURE, MEHRDAD. (2017). COMPARISON OF GABAPENTIN, PREGABALIN AND PLACEBO AS PREMEDICATION FOR ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 75(5), 367-373. SID. https://sid.ir/paper/38262/en

Vancouver: Copy

MAHOORI ALIREZA, HASSANI EBRAHIM, KARAMI NAZLI, AZIZPOURE MEHRDAD. COMPARISON OF GABAPENTIN, PREGABALIN AND PLACEBO AS PREMEDICATION FOR ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2017;75(5):367-373. Available from: https://sid.ir/paper/38262/en

IEEE: Copy

ALIREZA MAHOORI, EBRAHIM HASSANI, NAZLI KARAMI, and MEHRDAD AZIZPOURE, “COMPARISON OF GABAPENTIN, PREGABALIN AND PLACEBO AS PREMEDICATION FOR ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 75, no. 5, pp. 367–373, 2017, [Online]. Available: https://sid.ir/paper/38262/en

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