CHRONIC EFFECTS OF MUSTARD GAS ON LIVER PARENCHYMA IN RAT

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ZAKERIFARD A.; GHAHARI L.

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Journal: Annals of Military and Health Sciences Research Year:2006 | Volume:4 | Issue:1 (SERIAL NUMBER 13) Page(s): 725-728

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Title

CHRONIC EFFECTS OF MUSTARD GAS ON LIVER PARENCHYMA IN RAT

Author(s)

ZAKERIFARD A. | GHAHARI L. | Issue Writer Certificate

Keywords

LIVERQ3

RATQ3

SULFUR MUSTARDQ2

Abstract

Background: SULFUR MUSTARD (bis (2-chloroethyl) sulfide) is a strong alkylating agent with known mutagenic and suspected carcinogenic properties.Materials and methods: Eighty NMARI male RATs, 3 months old, were divided into eight groups (10 in each groups), were injected with 2.5,5 and 10 mg/kg SULFUR MUSTARD plus Tyrods buffer. RATs were kept under optimal hygienic condition, temperature 25°C, relative humidity 40 to 45% and light provided for a 12-h day/12- h night cycle. They were given water and rodent pellets. After 2 and 8 weeks RATs were killed. The samples were fixed in formaldehyde solution (%10), were stained with H&E and PAS and were studied with light microscope.Results: Increased blood cells in hepatic sinusoids, disappearance borders of LIVER lobules, irregulation of hepatic cord, apoptotic appearance of cells in lobule, and these signs were seen in 2/5 mg/kg (8 weeks), 5mg/kg (2 and 8 weeks) and 10 mg/kg (2 and 8 weeks) groups. Glycogen decreased in 5mg/kg (8 weeks) and 10 mg/kg (2 and 8 weeks) groups.Conclusions: All of changes were dependent on dosage and time duration.

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APA: Copy

ZAKERIFARD, A., & GHAHARI, L.. (2006). CHRONIC EFFECTS OF MUSTARD GAS ON LIVER PARENCHYMA IN RAT. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 4(1 (SERIAL NUMBER 13)), 725-728. SID. https://sid.ir/paper/382644/en

Vancouver: Copy

ZAKERIFARD A., GHAHARI L.. CHRONIC EFFECTS OF MUSTARD GAS ON LIVER PARENCHYMA IN RAT. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2006;4(1 (SERIAL NUMBER 13)):725-728. Available from: https://sid.ir/paper/382644/en

IEEE: Copy

A. ZAKERIFARD, and L. GHAHARI, “CHRONIC EFFECTS OF MUSTARD GAS ON LIVER PARENCHYMA IN RAT,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 4, no. 1 (SERIAL NUMBER 13), pp. 725–728, 2006, [Online]. Available: https://sid.ir/paper/382644/en

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