THE EVALUATION OF THE CLINICAL COURSE OF PATIENTS WITH SECONDARY PROGRESSIVE AND WORSENING RELAPSING REMITTING MULTIPLE SCLEROSIS (MS) TREATED WITH NOVANTRONE

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LOTFI J.; MEFTAHPOOR M.; SHARASBI A.A.; SOLTANZADEB A.

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2005 | Volume:62 | Issue:10 Page(s): 815-820

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Title

THE EVALUATION OF THE CLINICAL COURSE OF PATIENTS WITH SECONDARY PROGRESSIVE AND WORSENING RELAPSING REMITTING MULTIPLE SCLEROSIS (MS) TREATED WITH NOVANTRONE

Author(s)

LOTFI J. | MEFTAHPOOR M. | SHARASBI A.A. | SOLTANZADEB A. | Issue Writer Certificate

Keywords

DISABILITY EVALUATIONQ4

MITOXANTRONEQ4

MULTIPLE SCLEROSIS TREATMENTQ4

CHRONIC PROGRESSIVE MULTIPLE SCLEROSISQ4

RELAPSING-REMITTING MULTIPLE. SCLEROSISQ4

Abstract

Background: To evaluate clinical course of patients with progressive MS treated with novantrone. Materials and Methods: This was a one year interventional study of 35 patients with secondary progressive, worsening relapsing-remitting or progressive relapsing MS. Inclusion criteria"s were age <45 years, duration of the disease <15 years, Kurtzke expanded disability scale (EDSS) < 7,active course of the disease, no administration of any other immunomodulator agents. The patients were treated with 12mg/m2 of the cytotoxic agent Novantrone, administered every 3 months for 12 months. Clinical assessments were performed every 3 months. Disabilities at the entry and every 3 months were evaluated based on the EDSS. The number of exacerbations over the 12 months were recorded. Results: A statistically significant decrease in the mean number of exacerbations in worsening relapsing-remitting group was observed (P value=0.0001). The mean percentage of decreased attack was 82% (St. error = 4.84). Significant improvement on EDSS was seen during treatment compared with the time before treatment (P value=0.0001). Mean decrease in EDSS was 0.1743 (Std= 0.3230). EDSS change in progressive relapsing group was not significant (P value=0.406).The change in EDSS was not influenced by the duration of the disease or age. Conclusion: Our study suggests that Novantrone might be effective in reducing disease activity, both by decreasing the mean number of exacerbations and by slowing the clinical progression.

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APA: Copy

LOTFI, J., MEFTAHPOOR, M., SHARASBI, A.A., & SOLTANZADEB, A.. (2005). THE EVALUATION OF THE CLINICAL COURSE OF PATIENTS WITH SECONDARY PROGRESSIVE AND WORSENING RELAPSING REMITTING MULTIPLE SCLEROSIS (MS) TREATED WITH NOVANTRONE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(10), 815-820. SID. https://sid.ir/paper/38288/en

Vancouver: Copy

LOTFI J., MEFTAHPOOR M., SHARASBI A.A., SOLTANZADEB A.. THE EVALUATION OF THE CLINICAL COURSE OF PATIENTS WITH SECONDARY PROGRESSIVE AND WORSENING RELAPSING REMITTING MULTIPLE SCLEROSIS (MS) TREATED WITH NOVANTRONE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;62(10):815-820. Available from: https://sid.ir/paper/38288/en

IEEE: Copy

J. LOTFI, M. MEFTAHPOOR, A.A. SHARASBI, and A. SOLTANZADEB, “THE EVALUATION OF THE CLINICAL COURSE OF PATIENTS WITH SECONDARY PROGRESSIVE AND WORSENING RELAPSING REMITTING MULTIPLE SCLEROSIS (MS) TREATED WITH NOVANTRONE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 10, pp. 815–820, 2005, [Online]. Available: https://sid.ir/paper/38288/en

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