Effect of Low-level Laser Therapy on Bone Defect Repair in Diabetic and Osteoporotic Rats using the Real-Time PCR Technique

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Mostafavinia A.; BAYAT M.; Qatreh Samani M.; Ghoreishi S.K.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:28 | Issue:3 Page(s): 40-52

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Title

Effect of Low-level Laser Therapy on Bone Defect Repair in Diabetic and Osteoporotic Rats using the Real-Time PCR Technique

Author(s)

Mostafavinia A. | BAYAT M. | Qatreh Samani M. | Ghoreishi S.K. | Issue Writer Certificate

Keywords

Low-level laserQ1

OsteoporosisQ1

Partial bone defectQ1

Real-time PCRQ1

Type 1 diabetesQ1

Abstract

Introduction: Bone formation is disturbed in Type 1 diabetes followed by changes in the bone microstructure. The most important metabolic disorder in diabetes is Osteoporosis, which is characterized by bone loss and bone structure degradation. This study aimed to determine the effect of low-power laser on bone defect repair in the experimental model of diabetes and Osteoporosis. Materials & Methods: A total of 30 four-month-old female Wistar rats weighing 190-220 g were selected and randomly divided into six groups, including 1: non-diabetic control (Co. ), 2: non-diabetic laser (L. ), 3: diabetic control (Co. D. ), 4: diabetic laser (L. D. ), 5: diabetic alendronate (A. D. ), and 6: diabetic laser + alendronate (L. A. D. ). Diabetes was induced in groups 3, 4, 5, and 6. All groups underwent ovariectomy and Partial bone defect. In the laser group, a Low-level laser (890nm, 80 Hz, 1/5J / cm 2) was radiated to 3 points at the defect location. Tibia bones were collected, and Real-time PCR was performed after a month. The data were analyzed using ANOVA. A p-value less than P<0. 05 was considered statistically significant. Ethics code: 13237-91-1-1393-10397 Findings: The t-test showed a significant decrease in tibia bone density in diabetic and osteoporotic rats, compared to the non-diabetic control group. Moreover, analysis of gene expression data (ANOVA, P<0. 05) revealed a significant difference between the group of diabetic laser + alendronate and other groups in terms of Runx2 gene expression and Osteocalcin. Discussions & Conclusions: According to the findings, laser therapy combined with alendronate can accelerate the repair of Partial bone defect in the experimental model of diabetes and Osteoporosis.

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References

Age dependent alterations in osteoblast and osteoclast activity in human cancellous bone

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APA: Copy

Mostafavinia, A., BAYAT, M., Qatreh Samani, M., & Ghoreishi, S.K.. (2020). Effect of Low-level Laser Therapy on Bone Defect Repair in Diabetic and Osteoporotic Rats using the Real-Time PCR Technique. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 28(3 ), 40-52. SID. https://sid.ir/paper/383455/en

Vancouver: Copy

Mostafavinia A., BAYAT M., Qatreh Samani M., Ghoreishi S.K.. Effect of Low-level Laser Therapy on Bone Defect Repair in Diabetic and Osteoporotic Rats using the Real-Time PCR Technique. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;28(3 ):40-52. Available from: https://sid.ir/paper/383455/en

IEEE: Copy

A. Mostafavinia, M. BAYAT, M. Qatreh Samani, and S.K. Ghoreishi, “Effect of Low-level Laser Therapy on Bone Defect Repair in Diabetic and Osteoporotic Rats using the Real-Time PCR Technique,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 3 , pp. 40–52, 2020, [Online]. Available: https://sid.ir/paper/383455/en

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