THE EVALUATION OF ANTI-UV EFFECT OF SILYMARIN CREAM BASED ON CLINICAL AND PATHOLOGICAL FINDINGS

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AHMADI ASHTIANI HAMID REZA; HEKMAT NAZEMI NIMA; REZAZADEH SHAMSALI; GHOLAMHOSEINI BANAFSHEH; BAGHAEI MOHAMMAD; EHSANI AMIR HOUSHANG; RASTEGAR HOSEIN

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Journal: Tehran University Medical Journal Year:2010 | Volume:68 | Issue:6 Page(s): 321-329

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Title

THE EVALUATION OF ANTI-UV EFFECT OF SILYMARIN CREAM BASED ON CLINICAL AND PATHOLOGICAL FINDINGS

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Keywords

ULTRAVIOLET RADIATIONQ3

SILYMARINQ3

GUINEA PIGQ3

HISTOPATHOLOGYQ3

Abstract

Background: Nowadays skin damages caused by ultraviolet (U.V.) radiation from the sun were increased; accordingly necessity for safe and inexpensive protective products for reducing the harmful effects of this ray is unassailable. The antiradical, anti irritation and anti-cancer properties of SILYMARIN make it a suitable option for use in cream formulation to investigate its effect on skin disorders caused by U.V. radiation. In this research effect of local application of a cream containing SILYMARIN in prevention of the harmful effects of U.V. radiation on the GUINEA PIG skin were studied and evaluated by using histopathologic and clinical findings.Methods: 75 albino GUINEA PIGs were randomly divided into five groups of fifteens. 2cm2 of the back hair was shaven. In the first group no treatment was applied, in the second group vaseline, in group 3 base cream without SILYMARIN extract, in group 4 SILYMARIN extract and in group 5 cream containing SILYMARIN extract were used.Results: In clinical assessment, skin scaling, skin irregularity, erythema, skin hyperpigmentation, and edema were observed and in histopathological observation epidermal hyper keratosis, hyperpigmentation, exocytosis, acanthosis, chromatin discoloration in nucleus of epidermal squamous cells, perifolliculitis, dermal vascular hyperemia, edema and dermal thickness, infiltration of plasma cell lymphocytes and eosinophyls into dermis were detected. The statistical comparison of group 1 and group 5 shows statistically significant difference in most indices (p<0.01).Conclusions: Clinical and histopathologic examinations showed that local application of a cream containing SILYMARIN is effective in prevention of skin damage caused by U.V. radiation in GUINEA PIG’s skin, also the results of the clinical and histopathologic observation in this study confirm the enzymatic results in other researches.

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APA: Copy

AHMADI ASHTIANI, HAMID REZA, HEKMAT NAZEMI, NIMA, REZAZADEH, SHAMSALI, GHOLAMHOSEINI, BANAFSHEH, BAGHAEI, MOHAMMAD, EHSANI, AMIR HOUSHANG, & RASTEGAR, HOSEIN. (2010). THE EVALUATION OF ANTI-UV EFFECT OF SILYMARIN CREAM BASED ON CLINICAL AND PATHOLOGICAL FINDINGS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 68(6), 321-329. SID. https://sid.ir/paper/38353/en

Vancouver: Copy

AHMADI ASHTIANI HAMID REZA, HEKMAT NAZEMI NIMA, REZAZADEH SHAMSALI, GHOLAMHOSEINI BANAFSHEH, BAGHAEI MOHAMMAD, EHSANI AMIR HOUSHANG, RASTEGAR HOSEIN. THE EVALUATION OF ANTI-UV EFFECT OF SILYMARIN CREAM BASED ON CLINICAL AND PATHOLOGICAL FINDINGS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2010;68(6):321-329. Available from: https://sid.ir/paper/38353/en

IEEE: Copy

HAMID REZA AHMADI ASHTIANI, NIMA HEKMAT NAZEMI, SHAMSALI REZAZADEH, BANAFSHEH GHOLAMHOSEINI, MOHAMMAD BAGHAEI, AMIR HOUSHANG EHSANI, and HOSEIN RASTEGAR, “THE EVALUATION OF ANTI-UV EFFECT OF SILYMARIN CREAM BASED ON CLINICAL AND PATHOLOGICAL FINDINGS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 68, no. 6, pp. 321–329, 2010, [Online]. Available: https://sid.ir/paper/38353/en

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