Effect of N-acetyl-Cysteine on Serum Oxidative Stress Factors, lipid Particles and Glucose in Streptozotocin-Induced Alzheimeric Male Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DARBANDI N.; Tajiani m.; MOMENI H.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Guilan University of Medical Sciences Year:2018 | Volume:27 | Issue:106 Page(s): 54-64

Download Full-Text

Persian Verion

View:

331

Download:

Cites:

Information Journal Paper

Title

Effect of N-acetyl-Cysteine on Serum Oxidative Stress Factors, lipid Particles and Glucose in Streptozotocin-Induced Alzheimeric Male Rats

Author(s)

DARBANDI N. | Tajiani m. | MOMENI H.R. | Issue Writer Certificate

Keywords

Alzheimer DiseaseQ2

CysteineQ2

GlucoseQ2

LipidsQ2

Oxidative StressQ2

StreptozotocinQ1

Abstract

Introduction: Alzheimer’ s disease is a progressive degenerative disease which causes memory disorders, decreases cognitive func tions and behavioural changes. Some studies have indicated that antioxidants have a positive effect on the reduction of neuronal dam age disorders in the brain. Objective: In this study, the effects of N-acetyl-cysteine as a potent antioxidant on serum Oxidative Stress factors in Streptozotocin-induced Alzheimeric male rats were investigated. Materials and Methods: In this experimental study, 24 rats were divided into 4 groups; divided into four groups (n=8): Saline, Streptozotocin (STZ), Streptozotocin in combination with N-acetyl-cysteine (NAC) and NAC alone. Intracerebroventricular administrations of STZ (3mg/kg) on the first and the third day of the surgery and Intraperitoneally administrations of saline(ml/kg) or NAC (300mg/kg) on the fourth day after the surgery was performed. The animals’ memory was evaluated through passive task and Blood serums were used to measure the levels of malondialdehyde, total antioxidant, superoxide dismutase, Glucose and lipid particles. Results: STZ significantly reduced memory retrieval (p<0/001), decreased levels of total antioxidant (p<0/001) and superoxide dismutase (p<0/001) and increased lipid peroxidation level (p<0/001), compared with that in the control group. But no significant effect on Glucose level and lipid serum particles was observed, compared with the control group (p>0/05). Administration of NAC improved memory retrieval (p<0/001). The administration of NAC alone didn’ t have cause any significant difference, compared to the control group (p>0/05). Also, the injection of NAC led to decreased levels of Glucose (p<0/05), Triglyceride (p<0/001), LDL (p<0/001) and increased HDL(p<0/01) compared with the control group. Conclusion: It seems that NAC because of its antioxidant properties can reduce effect of memory impairment induced by STZ and it can be effective in prevention and treatment neurodegenerative diseases including Alzheimer Disease by modulating some risk factors such as Glucose, lipid particle and reducing of Oxidative Stress.

Cites

No record.

References

No record.

Cite

APA: Copy

DARBANDI, N., Tajiani, m., & MOMENI, H.R.. (2018). Effect of N-acetyl-Cysteine on Serum Oxidative Stress Factors, lipid Particles and Glucose in Streptozotocin-Induced Alzheimeric Male Rats. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 27(106 ), 54-64. SID. https://sid.ir/paper/383586/en

Vancouver: Copy

DARBANDI N., Tajiani m., MOMENI H.R.. Effect of N-acetyl-Cysteine on Serum Oxidative Stress Factors, lipid Particles and Glucose in Streptozotocin-Induced Alzheimeric Male Rats. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(106 ):54-64. Available from: https://sid.ir/paper/383586/en

IEEE: Copy

N. DARBANDI, m. Tajiani, and H.R. MOMENI, “Effect of N-acetyl-Cysteine on Serum Oxidative Stress Factors, lipid Particles and Glucose in Streptozotocin-Induced Alzheimeric Male Rats,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 106 , pp. 54–64, 2018, [Online]. Available: https://sid.ir/paper/383586/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops