Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer's Disease among Rats

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Seifi Nahavandi Bahareh; YAGHMAEI PARICHEHREH; AHMADIAN SHAHIN; EBRAHIM HABIBI AZADEH; Ghobeh Maryam

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2020 | Volume:14 | Issue:10 Page(s): 25-33

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Title

Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer's Disease among Rats

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Keywords

Alzheimer’Q1

s diseaseQ1

Amyloid beta-peptidesQ1

ExerciseQ1

RatsQ2

TerpinoleneQ2

Abstract

Background and Objectives: Alzheimer's disease is one of the most important neurodegenerative diseases that occur following the production of free radicals and inflammatory factors. Terpinolene has antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of Terpinolene and physical activity on memory and learning in a model of Alzheimer's Rats. Methods: Bilateral injection of AB1-42 was administered to the hippocampus of the male Rats to create the model of Alzheimer's disease. The assigned groups included control (-), sham, Exercise, control (+), Alzheimer's+distilled water, Alzheimer's+Exercise, Alzheimer's+Terpinolene (treatment), Alzheimer's+Terpinolene (prevention), and Alzheimer's+Terpinolene+Exercise. Superoxide dismutase (SOD), Malondialdehyde (MDA) level, shuttle box behavioral test, as well as neurogenesis and amyloid plaques were assessed in this study. The data were statistically analyzed using one-way ANOVA. Results: The SOD activity and neurogenesis levels decreased significantly in the control (+) group, compared to control groups of the behavioral test. However, the MDA level and plaque increased significantly (P<0. 05). Terpinolene intake and Exercise caused a significant increase in neurogenesis, a significant decrease in plaques, and significant changes in biochemical and behavioral parameters (P<0. 05). Conclusion: Based on the results of this study and previous reports on the antioxidant and anti-inflammatory effects of Terpinolene and Exercise, it seems that this combination along with Exercise can improve memory complications and disorders.

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APA: Copy

Seifi Nahavandi, Bahareh, YAGHMAEI, PARICHEHREH, AHMADIAN, SHAHIN, EBRAHIM HABIBI, AZADEH, & Ghobeh, Maryam. (2020). Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer's Disease among Rats. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 14(10 ), 25-33. SID. https://sid.ir/paper/383913/en

Vancouver: Copy

Seifi Nahavandi Bahareh, YAGHMAEI PARICHEHREH, AHMADIAN SHAHIN, EBRAHIM HABIBI AZADEH, Ghobeh Maryam. Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer's Disease among Rats. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2020;14(10 ):25-33. Available from: https://sid.ir/paper/383913/en

IEEE: Copy

Bahareh Seifi Nahavandi, PARICHEHREH YAGHMAEI, SHAHIN AHMADIAN, AZADEH EBRAHIM HABIBI, and Maryam Ghobeh, “Effects of Terpinolene and Physical Activity on Memory and Learning in a Model of Alzheimer's Disease among Rats,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 14, no. 10 , pp. 25–33, 2020, [Online]. Available: https://sid.ir/paper/383913/en

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