ADJUVANT EFFECT OF AN ACUTE MODERATE ENDURANCE EXERCISE IN HERPES SIMPLEX VIRUS 1 VACCINATION AND ITS BOOSTERS ON INTERLEUKIN 10 CYTOKINE AND GRANZYME B IN MICE

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Molanouri Shamsi Mahdieh; JAMALI AFSANE

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2018 | Volume:76 | Issue:2 Page(s): 96-102

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Title

ADJUVANT EFFECT OF AN ACUTE MODERATE ENDURANCE EXERCISE IN HERPES SIMPLEX VIRUS 1 VACCINATION AND ITS BOOSTERS ON INTERLEUKIN 10 CYTOKINE AND GRANZYME B IN MICE

Author(s)

Molanouri Shamsi Mahdieh | JAMALI AFSANE | Issue Writer Certificate

Keywords

EXERCISEQ1

HERPES SIMPLEXQ1

IMMUNE SYSTEMQ3

VACCINESQ2

Abstract

Background: The HERPES SIMPLEX viruses cause a variety of clinical illnesses that are painful and often distressing. To control the infection, the development of an effective vaccine that prevents or reduces the primary and recurrent infections would be of great significance. With considering to immunological changes following an acute endurance EXERCISE, the purpose of this study was to assess adjuvant effects of an acute endurance EXERCISE in first HERPES SIMPLEX virus 1 vaccine injection and its booster shots on interleukin-10 cytokine and granzyme B levels.Methods: This experimental study was carried out in Tarbiat Modares University during May to October 2016.32 BALB/c mice were divided into 4 groups: control, vaccine, vaccine plus an acute EXERCISE in first injection and vaccine plus an acute endurance EXERCISE in first injection and booster shots. Mice without or with access to acute endurance EXERCISE were immunized intramuscularly with inactivated KOS strain of HSV-1. Two weeks after three booster shots of vaccine, interleukin-10 and granzyme B levels were determined in spleen cell culture with enzyme-linked immunosorbent assay (ELISA) method.Results: This study was undertaken to test the hypothesis that an acute endurance EXERCISE as an adjuvant in HERPES SIMPLEX virus 1 vaccine can change interleukin-10 cytokine and granzyme B levels in mouse model. The result of this study showed significant differences between groups in interleukin-10 and granzyme B levels (P=0.001). Increasing in granzyme B levels with concurrent decreases in interleukin-10 levels was observed following using vaccine plus acute EXERCISE in first injection of vaccine and booster shots.Conclusion: It is suggested that EXERCISE may stimulate parameters related to cellular immunity and hence decrease the risk of infection decreased levels of interleukin-10 in experimental group that had vaccine plus acute EXERCISE in the first injection of vaccine and booster shots as an adjuvant was observed. These results demonstrate alternation of T helper 2 cells function and improve of cell immunity for protection against HERPES SIMPLEX virus 1 infections.

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APA: Copy

Molanouri Shamsi, Mahdieh, & JAMALI, AFSANE. (2018). ADJUVANT EFFECT OF AN ACUTE MODERATE ENDURANCE EXERCISE IN HERPES SIMPLEX VIRUS 1 VACCINATION AND ITS BOOSTERS ON INTERLEUKIN 10 CYTOKINE AND GRANZYME B IN MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 76(2 ), 96-102. SID. https://sid.ir/paper/38461/en

Vancouver: Copy

Molanouri Shamsi Mahdieh, JAMALI AFSANE. ADJUVANT EFFECT OF AN ACUTE MODERATE ENDURANCE EXERCISE IN HERPES SIMPLEX VIRUS 1 VACCINATION AND ITS BOOSTERS ON INTERLEUKIN 10 CYTOKINE AND GRANZYME B IN MICE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2018;76(2 ):96-102. Available from: https://sid.ir/paper/38461/en

IEEE: Copy

Mahdieh Molanouri Shamsi, and AFSANE JAMALI, “ADJUVANT EFFECT OF AN ACUTE MODERATE ENDURANCE EXERCISE IN HERPES SIMPLEX VIRUS 1 VACCINATION AND ITS BOOSTERS ON INTERLEUKIN 10 CYTOKINE AND GRANZYME B IN MICE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 76, no. 2 , pp. 96–102, 2018, [Online]. Available: https://sid.ir/paper/38461/en

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