EFFECT OF STATIC MAGNETIC FIELD ON APOPTOSIS INDUCTION AND ALTERING THE CELL CYCLE OF T-LYMPHOBLASTOID CELLS

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AHMADIANPOUR M.R.; ABDOLMALEKI P.; MOULA S.J.; HOSSEINKHANI S.

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Journal: Internal Medicine Today Year:2012 | Volume:18 | Issue:3 (57) Page(s): 87-94

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Title

EFFECT OF STATIC MAGNETIC FIELD ON APOPTOSIS INDUCTION AND ALTERING THE CELL CYCLE OF T-LYMPHOBLASTOID CELLS

Author(s)

AHMADIANPOUR M.R. | ABDOLMALEKI P. | MOULA S.J. | HOSSEINKHANI S. | Issue Writer Certificate

Keywords

APOPTOSISQ3

LUMINESCENCEQ2

STATIC MAGNETIC FIELD (SMF)Q2

FLOWCYTOMETRYQ3

JURKAT CELLQ2

Abstract

Aims: APOPTOSIS or programmed cell death is a normal physiological process of cell that leads to active and natural development and maintenance of tissue homeostasis. APOPTOSIS occurs due to different external factors. This study aimed to investigate a low risk method to induce APOPTOSIS in human leukemia cells using static magnetic field (SMF).Methods: In this laboratory research, the cultured human T-lymphoblastoid cell line (Jurkat E6.1), exposed to 6mT SMF for 6 and 24 hours. Luminometry, FLOWCYTOMETRY and western blot were used to measure total APOPTOSIS rate, primary APOPTOSIS rate and phosphorylated ATM and E2F1 proteins, respectively.Results: Increasing in the rate of APOPTOSIS in treated cells according to control cells was significant 36 hours after treatment with 6mT SMF for 6 (p=0.011) and 24 (p=0.055) hours.36 hours after treatment with 6mT SMF, the first significant difference was seen between treated and control cells (p<0.001).24 hours after cells exposure to 6mT SMF, cells population was decreased in G2 and S and 36 hours after treatment, the population was increased in G2 and S and decreased in G1. Exposure to 6mT SMF increased the amount of phosphorylated ATM protein in 1981 Serin and E2F1 protein in 31 Serin positions.Conclusion: 6mT SMF induces APOPTOSIS in exposed JURKAT CELLs by enhancing and activating ATM and E2F1 proteins.

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APA: Copy

AHMADIANPOUR, M.R., ABDOLMALEKI, P., MOULA, S.J., & HOSSEINKHANI, S.. (2012). EFFECT OF STATIC MAGNETIC FIELD ON APOPTOSIS INDUCTION AND ALTERING THE CELL CYCLE OF T-LYMPHOBLASTOID CELLS. OFOGH-E-DANESH, 18(3 (57)), 87-94. SID. https://sid.ir/paper/384872/en

Vancouver: Copy

AHMADIANPOUR M.R., ABDOLMALEKI P., MOULA S.J., HOSSEINKHANI S.. EFFECT OF STATIC MAGNETIC FIELD ON APOPTOSIS INDUCTION AND ALTERING THE CELL CYCLE OF T-LYMPHOBLASTOID CELLS. OFOGH-E-DANESH[Internet]. 2012;18(3 (57)):87-94. Available from: https://sid.ir/paper/384872/en

IEEE: Copy

M.R. AHMADIANPOUR, P. ABDOLMALEKI, S.J. MOULA, and S. HOSSEINKHANI, “EFFECT OF STATIC MAGNETIC FIELD ON APOPTOSIS INDUCTION AND ALTERING THE CELL CYCLE OF T-LYMPHOBLASTOID CELLS,” OFOGH-E-DANESH, vol. 18, no. 3 (57), pp. 87–94, 2012, [Online]. Available: https://sid.ir/paper/384872/en

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