PROGNOSTIC SIGNIFICANCE OF CERTAIN FEATURES IN CHILDREN WITH HEMOLYTIC UREMIC SYNDROME

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ATAEI N.; KHERADMAND K.; MADANI ABAS; MOHSENI P.; KHODADAD A.; RAMYAR A.; MAHDAVI ROUSHAN J.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2005 | Volume:62 | Issue:11 Page(s): 888-893

Download Full-Text

Persian Verion

View:

1,464

Download:

Cites:

Information Journal Paper

Title

PROGNOSTIC SIGNIFICANCE OF CERTAIN FEATURES IN CHILDREN WITH HEMOLYTIC UREMIC SYNDROME

Author(s)

Keywords

HEMOLYTIC UREMIC SYNDROMEQ4

ACUTE RENAL FAILUREQ4

PROGNOSTIC FEATURES OUTCOMEQ4

CHILDRENQ4

Abstract

Background: HEMOLYTIC UREMIC SYNDROME is defined as microangiopathic hemolytic anemia, thrombocytopenia and variable levels of renal failure. This syndrome is the most common cause of ACUTE RENAL FAILURE in early childhood. Several studies analyzing prognostic indicators have shown variable results with respect to age, prodrome, anuria, hypertension, proteinuria and central nervous system involvement. The purpose of this study was to assess. the prognostic significance of certain indicators in the outcome of the HEMOLYTIC UREMIC SYNDROME. Materials and Methods: In this study 80 patients with HEMOLYTIC UREMIC SYNDROME (HUS) from 1982 to 2002 which were admitted to the CHILDREN"s Hospital Medical Center were investigated through a Descriptive Retrospective case series (DRCS) study. The patients were divided into five prognostic categories as follows: group A, CrCI >75 ml/min group B, CrCI >75 ml/min/ 1.73m2 with proteinuria, hypertension or both, group C, 10 ml/min < CrCI <75 ml/min , group D, CrCl < 10 ml/min, group E, Death during acute phase of illness. Results: There were 41 boys and 39 girls. The mean age of the patients at presentation was 38.6 months (range 2 to 144 months). Out of28 CHILDREN (20 girls, 8 boys) died during the acute phase of the illness (18 as a result of their central nervous system complications, 5 cardiovascular (CV) disturbances, 1 septicemia and 4 unknown). Diarrhea (+) HUS was present in 61 (76.3%) patients (11 with acute watery diarrhea and 50 with a history of bloody diarrhea) and 19 (23.1%) with a recent history of upper respiratory tract infection. In the first 3 months after onset (acute phase) 86% of all CHILDREN needed dialysis therapy, 5% had creatinine clearance (CrCl) > 75 ml/min/ 1.73 m2, 64.6% had CrCl between 10 ml/min/ 1.73 m2 and 75 m1/min/ l.73 m2, and 30.4% had CrCl < 10 ml/min/ 1.73m2. The mortality rate in our group of CHILDREN was 35%. It was significantly higher in female than- male (71% versus 28.6% p<0.05). The rate of CrCl below 10 ml/min was significantly lower in patients under 4 years old (p=0.05). There was a positive correlation between CrCl bellow 75 ml/min/ 1.73m2 and major neurological symptoms or death than CHILDREN with (CrCl) > 75 ml/min/ 1.73m2 (p<0.05). In those CHILDREN with CrCl < 10 ml/min/ 1.73 m2, there was also a higher incidence of hypertension than CHILDREN with CrCl; over 10 ml/min/ 1.73 m2 (p<0.05). Conclusion: HUS has higher mortality. The immediate outcome was significantly poor in patients with either occurrence of major neurological signs or cardiovascular (CV) disturbances on admission, age over 4 years old, hypertension and female gender were also predictors of a worse prognosis.

Cites

No record.

References

No record.

Cite

APA: Copy

ATAEI, N., KHERADMAND, K., MADANI, ABAS, MOHSENI, P., KHODADAD, A., RAMYAR, A., & MAHDAVI ROUSHAN, J.. (2005). PROGNOSTIC SIGNIFICANCE OF CERTAIN FEATURES IN CHILDREN WITH HEMOLYTIC UREMIC SYNDROME. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(11), 888-893. SID. https://sid.ir/paper/38514/en

Vancouver: Copy

ATAEI N., KHERADMAND K., MADANI ABAS, MOHSENI P., KHODADAD A., RAMYAR A., MAHDAVI ROUSHAN J.. PROGNOSTIC SIGNIFICANCE OF CERTAIN FEATURES IN CHILDREN WITH HEMOLYTIC UREMIC SYNDROME. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;62(11):888-893. Available from: https://sid.ir/paper/38514/en

IEEE: Copy

N. ATAEI, K. KHERADMAND, ABAS MADANI, P. MOHSENI, A. KHODADAD, A. RAMYAR, and J. MAHDAVI ROUSHAN, “PROGNOSTIC SIGNIFICANCE OF CERTAIN FEATURES IN CHILDREN WITH HEMOLYTIC UREMIC SYNDROME,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 11, pp. 888–893, 2005, [Online]. Available: https://sid.ir/paper/38514/en

Related Journal Papers