CHOLESTEROL HOMEOSTASIS IN PATIENT WITH NEPHROTIC SYNDROME AND CONTROL GROUP

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DOUSTI M.; ZAVAR REZA J.; ARIA BARZIN S.; SOLEYMANI S.

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Journal: Tehran University Medical Journal Year:2005 | Volume:62 | Issue:11 Page(s): 967-972

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Information Journal Paper

Title

CHOLESTEROL HOMEOSTASIS IN PATIENT WITH NEPHROTIC SYNDROME AND CONTROL GROUP

Author(s)

DOUSTI M. | ZAVAR REZA J. | ARIA BARZIN S. | SOLEYMANI S. | Issue Writer Certificate

Keywords

NEPHROTIC SYNDROMEQ4

LIPOPROTEINS .TGQ4

TCQ4

LDL-CQ4

HDL-CQ4

APOBQ4

Abstract

Background: Lipids and lipoproteins abnormalities are characteristics of NEPHROTIC SYNDROME. The typical abnormalities include elevated concentration of serum TC, TG, LDL-C, APOB and decrease in HDL-C levels. Methods and Materials: In this study serum Triglyceride(TG), Total Cholesterol (TC), Low Density-Lipoprotein- Cholesterol (LDL-C) ,Apolipoprotein B (ApoB) and High-Density Lipoprotein-Cholesterol (HDL-C) levels determined in 24 male control grope(GI) and 27 male patient (GII) with NEPHROTIC SYNDROME .TG, TC were determined enzymaticly (Bohringer-Mannhein). HDL was isolated by ultracentrifugation. The concentration of LDL-C was Calculated (Fridewald), APOB concentration was determined by Nephlometry . Results: There were significant racial different in serum TG, TC, APOB, LDL-C and HDL-C between patients (GII)and controls(GI) (p<0.001,<0.001,<0.05 ,<0.001 and<0.001 respectively).The patients(GII)had higher levels of serum TG, TC, LDL-C, APOB and lower levels of serum HDL-C than control group (GI) . Conclusion: Patients with NEPHROTIC SYNDROME have multiple abnormalities in lipid and Lipoproteins (LP) metabolism .The elevated serum TC, TG, LDL-C and APOB levels and reduced serum HDL-C levels in patients (GII) may explain their higher rate of cardiovascular disease and as consequence ,the concept that atherogenesis might be accelerated by NEPHROTIC SYNDROME.

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APA: Copy

DOUSTI, M., ZAVAR REZA, J., ARIA BARZIN, S., & SOLEYMANI, S.. (2005). CHOLESTEROL HOMEOSTASIS IN PATIENT WITH NEPHROTIC SYNDROME AND CONTROL GROUP. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(11), 967-972. SID. https://sid.ir/paper/38520/en

Vancouver: Copy

DOUSTI M., ZAVAR REZA J., ARIA BARZIN S., SOLEYMANI S.. CHOLESTEROL HOMEOSTASIS IN PATIENT WITH NEPHROTIC SYNDROME AND CONTROL GROUP. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;62(11):967-972. Available from: https://sid.ir/paper/38520/en

IEEE: Copy

M. DOUSTI, J. ZAVAR REZA, S. ARIA BARZIN, and S. SOLEYMANI, “CHOLESTEROL HOMEOSTASIS IN PATIENT WITH NEPHROTIC SYNDROME AND CONTROL GROUP,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 11, pp. 967–972, 2005, [Online]. Available: https://sid.ir/paper/38520/en

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