RENAL STRUCTURAL AND FUNCTIONAL IMPROVEMENT BY ISCHEMIC PRECONDITIONING

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KADKHODAEI M.; ZAHMATKESH M.; FAGHIHI M.

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2005 | Volume:62 | Issue:11 Page(s): 936-941

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Title

RENAL STRUCTURAL AND FUNCTIONAL IMPROVEMENT BY ISCHEMIC PRECONDITIONING

Author(s)

KADKHODAEI M. | ZAHMATKESH M. | FAGHIHI M. | Issue Writer Certificate

Keywords

ISCHEMIAQ4

REPERFUSIONQ4

PRECONDITIONINGQ4

Abstract

Background: The term PRECONDITIONING refers to the paradoxical phenomenon in which pretreatment with a potential noxious stress-stimulus can increase cellular tolerance to subsequent noxious stress-stimuli. Ischemic injury to the kidney is associated with high mortality. Improving the ability of this organ to tolerate ischemic injury is important and may be achieved by repetitive short periods of ISCHEMIA and REPERFUSION. In previous study, we showed that prior induction of brief periods of ISCHEMIA-reperfusion (IR) by clamping the right renal artery prevents reduction in vitamin E levels during subsequent renal IR. In the present study, we investigated whether this model of ischemic PRECONDITIONING (IPC) could improve renal function and structure in subsequent IR. Renal tissues were evaluated histologically and serum BUN & creatinine as renal functional indices were measured. Materials and Methods: 28 adult male Sprague-Dawley rats weighing 200-250 g were randomly divided in to 4 groups (Control, IR, IPC and IPC-IR). In the IR group, right renal artery clamped for 30 min followed by 10 min REPERFUSION. IPC group has experienced 3 periods of intermittent "5 min ISCHEMIA" followed by "5 min REPERFUSION". IPC-IR group was experienced both conditions, first IPC and then IR. Duration of the procedure was the same in all groups. At the end of the procedure, blood samples were drawn from right renal vein for serum BUN &. creatinine measurements and kidney was formalin fixed for histological evaluations. Results: The results showed that 30 min ISCHEMIA in IR group significantly (P<0.05) reduced renal function demonstrating by increase in serum creatinine levels as compared with the control group. These results in IPC group also showed a significant difference with IR: group but no significant difference in serum BUN and creatinine between IR and IPC-IR group Were detected. Histological evaluation showed no structural damage in IPC group and minor trend to improvement in IPC-IR group. Conclusion: Our findings suggest that, this model of PRECONDITIONING couldn"t highly improve renal function in the early phase of REPERFUSION but the structural damage in the IPC-IR group Was lower than that of the IR group. The protective functional effects of PRECONDITIONING in the late phase needs more study.

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References

EFFECTS OF ISCHEMIC PRECONDITIONING ON THE RENAL ISCHEMIA- REPERFUSION INJURY

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APA: Copy

KADKHODAEI, M., ZAHMATKESH, M., & FAGHIHI, M.. (2005). RENAL STRUCTURAL AND FUNCTIONAL IMPROVEMENT BY ISCHEMIC PRECONDITIONING. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(11), 936-941. SID. https://sid.ir/paper/38521/en

Vancouver: Copy

KADKHODAEI M., ZAHMATKESH M., FAGHIHI M.. RENAL STRUCTURAL AND FUNCTIONAL IMPROVEMENT BY ISCHEMIC PRECONDITIONING. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2005;62(11):936-941. Available from: https://sid.ir/paper/38521/en

IEEE: Copy

M. KADKHODAEI, M. ZAHMATKESH, and M. FAGHIHI, “RENAL STRUCTURAL AND FUNCTIONAL IMPROVEMENT BY ISCHEMIC PRECONDITIONING,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 11, pp. 936–941, 2005, [Online]. Available: https://sid.ir/paper/38521/en

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