The Effect of Hesperidin on the Cognitive-Behavioral Deficit in a Rat Model of PentylenetetrazoleInduced Perinatal Seizures

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Khodabandeh Habibollah; Keshavarzi Shaghayegh; Moradian Pariya; EDALATMANESH MOHAMMAD AMIN

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Journal: Neuroscience Journal of Shefaye Khatam Year:2020 | Volume:8 | Issue:4 Page(s): 1-11

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Title

The Effect of Hesperidin on the Cognitive-Behavioral Deficit in a Rat Model of PentylenetetrazoleInduced Perinatal Seizures

Author(s)

Khodabandeh Habibollah | Keshavarzi Shaghayegh | Moradian Pariya | EDALATMANESH MOHAMMAD AMIN | Issue Writer Certificate

Keywords

SeizuresQ2

PregnancyQ1

CognitionQ2

RatsQ2

Abstract

Introduction: Perinatal seizure with inducing oxidative stress causes serious damage to the fetal central nervous system and leads to cognitive-behavioral deficits. This study evaluates the effect of Hesperidin (HES) on cognitive and behavioral deficits in Rats following perinatal Seizures. Materials and Method: 30 Wistar pregnant Rats were randomly divided into 5 groups: control, pentylenetetrazole (PTZ) + NS, PTZ + HES 25, PTZ + HES50, and PTZ + HES 100. Animals were treated with repeated PTZ administration (40 mg/kg, intraperitoneally) from gestation day 14 for 5 consecutive days. Two hours before PTZ injection, the PTZ+NS group and the PTZ+HES groups were gavaged with either normal saline or HES (25, 50, or 100 mg/kg), respectively. The severity of seizure, delay in onset of a seizure in mothers, working and avoidance memory, and anxiety-like behaviors were assessed in one-month-old male infants. Results: A significant increase in seizure severity and a decrease in seizure delay were seen in PTZ-treated mothers. On the other hand, a significant decrease in behavior changes, avoidance memory, and hippocampal cell density was observed with increased anxiety levels in the infant of the PTZ+NS group compared to the control Rats. However, HES-treated groups showed a significant increase in working and passive avoidance memory with a decreasing level of anxiety compared to the PTZ+NS group. Conclusion: HES has anticonvulsant, anxiolytic, and memory-enhancing effects in the perinatal Seizures in Rats.

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APA: Copy

Khodabandeh, Habibollah, Keshavarzi, Shaghayegh, Moradian, Pariya, & EDALATMANESH, MOHAMMAD AMIN. (2020). The Effect of Hesperidin on the Cognitive-Behavioral Deficit in a Rat Model of PentylenetetrazoleInduced Perinatal Seizures. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 8(4 ), 1-11. SID. https://sid.ir/paper/385712/en

Vancouver: Copy

Khodabandeh Habibollah, Keshavarzi Shaghayegh, Moradian Pariya, EDALATMANESH MOHAMMAD AMIN. The Effect of Hesperidin on the Cognitive-Behavioral Deficit in a Rat Model of PentylenetetrazoleInduced Perinatal Seizures. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2020;8(4 ):1-11. Available from: https://sid.ir/paper/385712/en

IEEE: Copy

Habibollah Khodabandeh, Shaghayegh Keshavarzi, Pariya Moradian, and MOHAMMAD AMIN EDALATMANESH, “The Effect of Hesperidin on the Cognitive-Behavioral Deficit in a Rat Model of PentylenetetrazoleInduced Perinatal Seizures,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 8, no. 4 , pp. 1–11, 2020, [Online]. Available: https://sid.ir/paper/385712/en

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