HLA-DRB, DQA1 AND DQB1 ALLELES AND HAPLOTYPES FRECUENCY IN IRANIAN PULMONAR TUBERCULOSIS PATIENTS AND NORMAL CONTROL

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JABARI H.; AMIR ZARGAR A.; HAJI ABD ALBAGHI MAHBOUBEH; NIKBIN B.; KHOSRAVI F.; NIKNAM MANDANA; ANSARI B.; MORADI B.; YALDA A.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2003 | Volume:61 | Issue:1 Page(s): 80-89

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Title

HLA-DRB, DQA1 AND DQB1 ALLELES AND HAPLOTYPES FRECUENCY IN IRANIAN PULMONAR TUBERCULOSIS PATIENTS AND NORMAL CONTROL

Author(s)

Keywords

HLA (HUMAN LEUKOCYTE ANTIGEN)Q4

P.T.B. (PULMONARY TUBERCULOSIS)Q4

PCR (PULMONARY CHAIN REACTION)Q4

Abstract

Introduction: Tuberculosis is the most widespread epidemy of the world. It is estimated that one third of the worlds population are infected with mycoboacterium tuberculosis, producing a burden of 8-10 millions of new cases and 3 millions of dead" each year in the world. Epidemiological studies are indicating that genetic susceptibility can predispose to prevent from tuberculosis infection and its severity.Methods and Materials: In the present case-control analytic study, 40 sputum positive pulmonary T. B. patients HLA-class II alleles (DRB, DQA 1 and DQB 1) are detected and compared with 100 healthy subjects by PCR-ssp method for the first time in Iran.Results: The frequencies of alleles DQA1 *0101 [OR: 2.662 (95% CI: 1.15-6.44) and DRB*07 (Pc= 0.0252, OR: 2.710 (95% CI: 1.197-6.135) were significantly) increased in P.T.B patients when compared with healthy subjects. By contrast, frequencies of alleles DQA1*0301 [OR: 0.254 (95% CI: 0.075-0.865): and DQA1* 0501 [OR: 0.539 (95% CI: 0.304-0.954)] were significantly decreased it patients with P.T.B. There was no significant statistical predisposition/ prevention it DQB 1 locus alleles frequency or any haplotype disequilibrium.Conclusion: The HLA system appears to have an important genetic influence on P.T.B. development.

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APA: Copy

JABARI, H., AMIR ZARGAR, A., HAJI ABD ALBAGHI, MAHBOUBEH, NIKBIN, B., KHOSRAVI, F., NIKNAM, MANDANA, ANSARI, B., MORADI, B., & YALDA, A.. (2003). HLA-DRB, DQA1 AND DQB1 ALLELES AND HAPLOTYPES FRECUENCY IN IRANIAN PULMONAR TUBERCULOSIS PATIENTS AND NORMAL CONTROL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 61(1), 80-89. SID. https://sid.ir/paper/38608/en

Vancouver: Copy

JABARI H., AMIR ZARGAR A., HAJI ABD ALBAGHI MAHBOUBEH, NIKBIN B., KHOSRAVI F., NIKNAM MANDANA, ANSARI B., MORADI B., YALDA A.. HLA-DRB, DQA1 AND DQB1 ALLELES AND HAPLOTYPES FRECUENCY IN IRANIAN PULMONAR TUBERCULOSIS PATIENTS AND NORMAL CONTROL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2003;61(1):80-89. Available from: https://sid.ir/paper/38608/en

IEEE: Copy

H. JABARI, A. AMIR ZARGAR, MAHBOUBEH HAJI ABD ALBAGHI, B. NIKBIN, F. KHOSRAVI, MANDANA NIKNAM, B. ANSARI, B. MORADI, and A. YALDA, “HLA-DRB, DQA1 AND DQB1 ALLELES AND HAPLOTYPES FRECUENCY IN IRANIAN PULMONAR TUBERCULOSIS PATIENTS AND NORMAL CONTROL,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 61, no. 1, pp. 80–89, 2003, [Online]. Available: https://sid.ir/paper/38608/en

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