RELATIONSHIP BETWEEN ADPKD AND POST-RENAL TRANSPLANT DIABETES MELLITUS

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SEYFI SEPIDEH; SOLEYMANI AZAM; LESANPEZESHKI M.; EYN ELAHI BEHZAD; KHATAMI M.R.; MAHDAVI MAZDEH M.; AHMADI F.L.; MAZIYAR S.

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Journal: Tehran University Medical Journal Year:2006 | Volume:64 | Issue:8 Page(s): 68-73

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Title

RELATIONSHIP BETWEEN ADPKD AND POST-RENAL TRANSPLANT DIABETES MELLITUS

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Keywords

ESRDQ3

PTDMQ3

ADPKDQ3

Abstract

Background: Autosomal-dominant polycystic kidney disease (ADPKD), a common hereditary disease, is characterized by the progressive development and enlargement of multiple cysts in both kidneys, and typically resulting in end stage renal disease (ESRD) by the fifth decade of life. Post-transplant diabetes mellitus (PTDM), a common complication after transplantation with an incidence rate of 2.5-20%, is associated with poor graft and patient survival. In few studies, PTDM has been more frequent in ADPKD transplanted patients. In the present study, we investigated whether there is any association between PTDM and ADPKD in our patients.Methods: In this prospective study, 140 non-diabetic and nonsmoker successfully transplanted patients (27 ADPKD and 113 non ADPKD patients) were enrolled during three years. Both groups were matched for age, sex, body mass index (BMI), duration of renal replacement therapy before transplantation and also immunosuppressive protocols after transplant. Post-transplant diabetes mellitus was defined as Clinical Practice Guidelines advocated by Canadian Diabetes Association. All patients were followed for 12 months.Results: PTDM occurred in 11.1% of ADPKD patients and in 13.1% of control group which was statistically insignificant (P>0.05). The development of PTDM in ADPKD group was not related to sex, age, and hypertension, duration of renal replacement therapy before transplantation, BMI and serum creatinine levels (P>0.05).Conclusion: Post-transplant diabetes mellitus appears not to be associated with autosomal-dominant polycystic kidney disease as an etiology of end stage renal disease.

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APA: Copy

SEYFI, SEPIDEH, LESANPEZESHKI, M., EYN ELAHI, BEHZAD, KHATAMI, M.R., MAHDAVI MAZDEH, M., AHMADI, F.L., MAZIYAR, S., & SOLEYMANI, AZAM. (2006). RELATIONSHIP BETWEEN ADPKD AND POST-RENAL TRANSPLANT DIABETES MELLITUS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 64(8), 68-73. SID. https://sid.ir/paper/38632/en

Vancouver: Copy

SEYFI SEPIDEH, LESANPEZESHKI M., EYN ELAHI BEHZAD, KHATAMI M.R., MAHDAVI MAZDEH M., AHMADI F.L., MAZIYAR S., SOLEYMANI AZAM. RELATIONSHIP BETWEEN ADPKD AND POST-RENAL TRANSPLANT DIABETES MELLITUS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2006;64(8):68-73. Available from: https://sid.ir/paper/38632/en

IEEE: Copy

SEPIDEH SEYFI, M. LESANPEZESHKI, BEHZAD EYN ELAHI, M.R. KHATAMI, M. MAHDAVI MAZDEH, F.L. AHMADI, S. MAZIYAR, and AZAM SOLEYMANI, “RELATIONSHIP BETWEEN ADPKD AND POST-RENAL TRANSPLANT DIABETES MELLITUS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 64, no. 8, pp. 68–73, 2006, [Online]. Available: https://sid.ir/paper/38632/en

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